Heat shock factors: integrators of cell stress, development and lifespan

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: Åkerfelt M, Morimoto RI, Sistonen L
Publication year: 2010
Journal: Nature Reviews Molecular Cell Biology
Journal acronym: NAT REV MOL CELL BIO
Volume number: 11
Issue number: 8
Start page: 545
End page: 555
Number of pages: 11
ISSN: 1471-0072
eISSN: 1471-0080


Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and lifespan-enhancing pathways, and the repertoire of HSF targets has thus expanded well beyond the heat shock genes. These unexpected observations have uncovered complex layers of post-translational regulation of HSFs that integrate the metabolic state of the cell with stress biology, and in doing so control fundamental aspects of the health of the proteome and ageing.

Last updated on 2020-06-08 at 06:32