Neuronal cells show regulatory differences in the hsp70 gene response

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Kaarniranta K, Oksala N, Karjalainen HM, Suuronen T, Sistonen L, Helminen HJ, Salminen A, Lammi MJ
Publisher: ELSEVIER SCIENCE BV
Publication year: 2002
Journal: Molecular Brain Research
Journal acronym: MOL BRAIN RES
Volume number: 101
Issue number: 1-2
Start page: 136
End page: 140
Number of pages: 5
ISSN: 0169-328X
eISSN: 1872-6941


Abstract

The synthesis of heat shock proteins (Hsps), encoded by heat shock genes, is increased in response to various stress stimuli. Hsps function as molecular chaperones, they dissociate cytotoxic stress-induced protein aggregates within cells and ensure improved survival. Induction of heat shock genes is mainly regulated at the transcriptional level. The stress responsive transcription factor, heat shock factor 1 (HSF1), is involved in the transcriptional induction of the heat shock genes. Our objective was to examine how hsp70 genes are regulated in different transformed and primary neurons upon exposure to elevated temperature. Our findings reveal that the Hsp70 response is regulated at the translational level in Neuro-2a neuroblastoma cells. while the IMR-32 neuroblastoma cells respond to stress by the classical HSF1-driven transcriptional regulatory mechanism. Primary rat hippocampal neurons show a lack of HSF1 and induction of the hsp70 gene. These observations suggest that neuronal cells display different hsp70 gene expression patterns which range from undetected response to transcriptional and posttranscriptional regulation during heat stress.


Keywords

heat stress

Last updated on 2019-14-10 at 03:56