Iron catalyzed halogenation of benzylic aldehydes and ketones

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

Interna författare/redaktörer

Publikationens författare: Risto Savela, Johan Wärnå, Dmitry Yu. Murzin, Reko Leino
Publiceringsår: 2015
Tidskrift: Catalysis Science and Technology
Tidskriftsakronym: CATAL SCI TECHNOL
Volym: 5
Nummer: 4
Artikelns första sida, sidnummer: 2406
Artikelns sista sida, sidnummer: 2417
Antal sidor: 12
ISSN: 2044-4753
eISSN: 2044-4761


A simple and efficient iron-catalyzed method for chlorination of aromatic carbonyl compounds is reported. By using 4-10 mol% Fe(III) oxo acetate catalyst, prepared by solid state atmospheric oxidation of Fe(II) acetate, in combination with triethylsilane and chlorotrimethylsilane, hydrosilylation of benzylic carbonyl compounds with subsequent chlorination is achieved within a few hours at room temperature. This new method is mild and rapid compared to the conventional two step approach involving reduction and chlorination reactions in separate stages. Development of synthetic methodology is also supplemented here by kinetic investigation of the reaction mechanism, which supports the tentative mechanisms suggested previously for similar reactions.

Senast uppdaterad 2019-07-12 vid 03:15