A New Mathematical Model for the Heat Shock Response

A3 Book section, Chapters in research books

Internal Authors/Editors

Publication Details

List of Authors: Petre I, Mizera A, Hyder CL, Mikhailov A, Eriksson JE, Sistonen L, Back RJ
Editors: Anne Condon, David Harel, Joost N. Kok, Arto Salomaa, Erik Winfree
Publisher: Springer
Publication year: 2009
Publisher: Springer
Book title: Algorithmic bioprocesses
Title of series: Natural Computing Series
Start page: 411
End page: 425
Number of pages: 15
ISBN: 9783540888697


We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.

Last updated on 2020-28-09 at 03:38