Canonical transient receptor potential channel 2 (TRPC2): old name-new games. Importance in regulating of rat thyroid cell physiology

A2 Review article, Literature review, Systematic review


Internal Authors/Editors


Publication Details

List of Authors: Törnquist K, Sukumaran P, Kemppainen K, Löf C, Viitanen T
Publisher: SPRINGER
Publication year: 2014
Journal: Pflügers Archiv European Journal of Physiology
Journal acronym: PFLUG ARCH EUR J PHY
Volume number: 466
Issue number: 11
Start page: 2025
End page: 2034
Number of pages: 10
ISSN: 0031-6768
eISSN: 1432-2013


Abstract


  1. In addition to the TSH-cyclic AMP signalling pathway, calcium signalling is of crucial importance in thyroid cells. Although the importance of calcium signalling has been thoroughly investigated for several decades, the nature of the calcium channels involved in signalling is unknown. In a recent series of investigations using the well-studied rat thyroid FRTL-5 cell line, we showed that these cells exclusively express the transient receptor potential canonical 2 (TRPC2) channel. Our results suggested that the TRPC2 channel is of significant importance in regulating thyroid cell function. These investigations were the first to show that thyroid cells express a member of the TRPC family of ion channels. In this review, we will describe the importance of the TRPC2 channel in regulating TSH receptor expression, thyroglobulin maturation, intracellular calcium and iodide homeostasis and that the channel also regulates thyroid cell proliferation.


Keywords

Intracellular calcium, Rat, Receptor, Thyroid, TRPC2, TSH

Last updated on 2019-16-09 at 06:21