Chemopreventive effects of hydroxymatairesinol on uterine carcinogenesis in Donryu rats

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Katsuda S, Yoshida M, Saarinen N, Smeds A, Nakae D, Santti R, Maekawa A
Förläggare: SOC EXPERIMENTAL BIOLOGY MEDICINE
Publiceringsår: 2004
Tidskrift: Experimental Biology and Medicine
Tidskriftsakronym: EXP BIOL MED
Volym: 229
Nummer: 5
Artikelns första sida, sidnummer: 417
Artikelns sista sida, sidnummer: 424
Antal sidor: 8
ISSN: 1535-3702


Abstrakt

Hydroxymatairesinol (HMR), obtained from the heartwood of spruce (Picea abies), has been demonstrated to exert chemopreventive effects on the development of mammary tumors in rats. To examine the influence of HMR on uterine carcinogenesis, adult Donryu rats were initiated with a single uterine treatment of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) at 11 weeks of age and fed thereafter 0, 200, or 600 ppm HMR mixed in the soy-containing diet until 15 months of age. Incidences of uterine adenocarcinoma in both 200 and 600 ppm HMR-dosed groups were significantly reduced to 11% and 15%, respectively, less than 50% of 0 ppm, at the end of the experiment (P < 0.05). A delay in the start of persistent estrus by HMR was observed at 8 months of age compared with controls given carcinogen alone. From urinalysis, HMR was metabolized mainly to enterolactone and hydroxyenterolactone. These findings suggest that HMR or its metabolites exert chemopreventive effects in the rat ENNG-uterine carcinogenesis model.


Nyckelord

chemoprevention, endometrial adenocarcinoma, hydroxymatairesinol, rat

Senast uppdaterad 2019-23-09 vid 05:56