Chemopreventive effects of hydroxymatairesinol on uterine carcinogenesis in Donryu rats

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Katsuda S, Yoshida M, Saarinen N, Smeds A, Nakae D, Santti R, Maekawa A
Publisher: SOC EXPERIMENTAL BIOLOGY MEDICINE
Publication year: 2004
Journal: Experimental Biology and Medicine
Journal acronym: EXP BIOL MED
Volume number: 229
Issue number: 5
Start page: 417
End page: 424
Number of pages: 8
ISSN: 1535-3702


Abstract

Hydroxymatairesinol (HMR), obtained from the heartwood of spruce (Picea abies), has been demonstrated to exert chemopreventive effects on the development of mammary tumors in rats. To examine the influence of HMR on uterine carcinogenesis, adult Donryu rats were initiated with a single uterine treatment of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) at 11 weeks of age and fed thereafter 0, 200, or 600 ppm HMR mixed in the soy-containing diet until 15 months of age. Incidences of uterine adenocarcinoma in both 200 and 600 ppm HMR-dosed groups were significantly reduced to 11% and 15%, respectively, less than 50% of 0 ppm, at the end of the experiment (P < 0.05). A delay in the start of persistent estrus by HMR was observed at 8 months of age compared with controls given carcinogen alone. From urinalysis, HMR was metabolized mainly to enterolactone and hydroxyenterolactone. These findings suggest that HMR or its metabolites exert chemopreventive effects in the rat ENNG-uterine carcinogenesis model.


Keywords

chemoprevention, endometrial adenocarcinoma, hydroxymatairesinol, rat

Last updated on 2019-22-08 at 05:39