Antithrombotic properties of sulfated wood-derived galactoglucomannans

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Ales Doliska, Stefan Willför, Simona Strnad, Volker Ribitsch, Karin Stana Kleinschek, Patrik Eklund, Chunlin Xu
Publisher: WALTER DE GRUYTER GMBH
Publication year: 2012
Journal: Holzforschung
Journal acronym: HOLZFORSCHUNG
Volume number: 66
Issue number: 2
Start page: 149
End page: 154
Number of pages: 6
ISSN: 0018-3830


Abstract

Galactoglucomannans (GGMs) are water-soluble polysaccharides released and accumulated in process waters in the production of thermomechanical pulp. The general trend in the forestry industry is moving towards bio-refineries, for example utilizing these hemicelluloses as bioactive substances. At present, there is no industrial use of wood-derived mannans. In this study, GGMs extracted from thermomechanical pulp, as well as further carboxymethylated galactoglucomannans (CM-GGMs), were sulfated to increase their antithrombotic properties. The products were characterized with Fourier transform infrared spectroscopy, nuclear magnetic resonance and capillary electrophoresis. The carbohydrate composition and sulfur amounts were determined. The products' total charges were determined by polyelectrolyte titrations and their antithrombotic effect was measured based on the activated partial thromboplastin time. The results showed a significant increase in the antithrombotic effect of the sulfated galactoglucomannans from spruce wood and thus a potential new use for wood-derived mannans.


Keywords

activated partial thromboplastin time, anticoagulant, antithrombocity, carboxymethylation, galactoglucomannan, spruce wood, sulfated polysaccharide

Last updated on 2019-13-12 at 03:45