Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

Interna författare/redaktörer

Publikationens författare: Karvinen S, Silvennoinen M, Vainio P, Sistonen L, Koch LG, Britton SL, Kainulainen H
Publiceringsår: 2016
Tidskrift: Experimental Gerontology
Tidskriftsakronym: EXP GERONTOL
Volym: 79
Artikelns första sida, sidnummer: 46
Artikelns sista sida, sidnummer: 54
Antal sidor: 9
ISSN: 0531-5565


Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.


aging, oxidative stress, physical activity, sirtuin, skeletal muscle

Senast uppdaterad 2020-21-09 vid 06:41