Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Karvinen S, Silvennoinen M, Vainio P, Sistonen L, Koch LG, Britton SL, Kainulainen H
Publication year: 2016
Journal: Experimental Gerontology
Journal acronym: EXP GERONTOL
Volume number: 79
Start page: 46
End page: 54
Number of pages: 9
ISSN: 0531-5565


Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.


aging, oxidative stress, physical activity, sirtuin, skeletal muscle

Last updated on 2020-25-09 at 06:14