Lipase catalysis in the preparation of 3-(1-amino-3-butenyl)pyridine enantiomers

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Ari Hietanen, Tiina Saloranta, Reko Leino, Liisa T. Kanerva
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication year: 2012
Journal: Tetrahedron: Asymmetry
Journal acronym: TETRAHEDRON-ASYMMETR
Volume number: 23
Issue number: 24
Start page: 1629
End page: 1632
Number of pages: 4
ISSN: 0957-4166


Abstract

The kinetic resolution of 1-(3-pyridyl)buten-3-ylamine with activated and non-activated acyl donors and Burkholderia cepacia lipase (lipase PS-D) under dry conditions has been studied. The N-acylation in isopropyl acetate (E > 100) and the acidic hydrolysis of the (R)-amide produced gave the corresponding enantiomerically enriched amines. (C) 2012 Elsevier Ltd. All rights reserved.

Last updated on 2020-23-01 at 02:05