Enabling flexible dosing in orodispersible paediatric formulations by means of solvent casting and thermal inkjet printing

B1 Icke-referentgranskade tidskriftsartiklar


Interna författare/redaktörer


Publikationens författare: Heidi Öblom, Ines Pollmann, Diti Desai, Ezgi Özliseli, Jessica Rosenholm, Maren Preis
Redaktörer: Smita Salunke, Catherine Tuleu
Publiceringsår: 2018
Tidskrift: International Journal of Pharmaceutics
Moderpublikationens namn: Formulating Better Medicines for Children – European Paediatric Formulation Initiative (EuPFI) 2016
Volym: 536
Artikelns första sida, sidnummer: 495
Artikelns sista sida, sidnummer: 496


Abstrakt

Introduction: Providing and enabling flexible dosing options for drugs with a specific need in the paediatric population is a major topic in the recent years. Innovative approaches regarding orodispersible dosage form for paediatric use became more and more popular (Preis, 2015). Latest research includes the application of printing technologies by using drug-loaded inks to obtain even more flexibility with regard to individual dosing (Preis and Sandler, 2016).

Purpose: The purpose of this study was to investigate different methods to prepare drug-loaded orodispersible films. Besides the conventional preparation using a solvent casting approach using the pure drug and drug-loaded mesoporous nanoparticles, the suitability to use a readily available desktop thermal inkjet printer to load drug-free films with variable doses for paediatrics was studied.

Conclusion: Two drugs with a specific need for paediatric formulations were successfully processed in orodispersible films. The inkjet printing procedure could be shown as a convenient method to obtain a variety of doses. Furthermore, printing of dosage forms


Senast uppdaterad 2019-15-12 vid 04:50