The plant lignans matairesinol and secoisolariciresinol administered to Min mice do not protect against intestinal tumor formation

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Anne-Maria Pajari, Annika I. Smeds, Seija I. Oikarinen, Patrik C. Eklund, Rainer E. Sjöholm, Marja Mutanen
Förläggare: ELSEVIER IRELAND LTD
Publiceringsår: 2006
Tidskrift: Cancer Letters
Tidskriftsakronym: CANCER LETT
Volym: 233
Nummer: 2
Artikelns första sida, sidnummer: 309
Artikelns sista sida, sidnummer: 314
Antal sidor: 6
ISSN: 0304-3835


Abstrakt

The lignans matairesinol (MAT) and secoisolariciresinol (SECO) were fed to Min mice at 0.02% (w/w) in diet to study their effects on intestinal tumor development. The mean number (67 vs. 5 1, P = 0.052) and size (1.4 vs. 1.2 mm, P=0.011) of tumors in the MAT group was elevated when compared with the control group. Tumor formation of the SECO group did not differ from the control group. Intake of MAT increased the level of both MAT and enterolactone in the plasma while SECO feeding increased SECO, enterodiol, and enterolactone (P=0.001). These results showed that MAT or SECO do not prevent intestinal carcinogenesis in Min mice and that MAT may have adverse effects. (c) 2005 Elsevier Ireland Ltd. All rights reserved.


Nyckelord

colon cancer, matairesinol, Min mice, secoisolariciresinol

Senast uppdaterad 2019-15-12 vid 05:15