The plant lignans matairesinol and secoisolariciresinol administered to Min mice do not protect against intestinal tumor formation

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Anne-Maria Pajari, Annika I. Smeds, Seija I. Oikarinen, Patrik C. Eklund, Rainer E. Sjöholm, Marja Mutanen
Publication year: 2006
Journal: Cancer Letters
Journal acronym: CANCER LETT
Volume number: 233
Issue number: 2
Start page: 309
End page: 314
Number of pages: 6
ISSN: 0304-3835


The lignans matairesinol (MAT) and secoisolariciresinol (SECO) were fed to Min mice at 0.02% (w/w) in diet to study their effects on intestinal tumor development. The mean number (67 vs. 5 1, P = 0.052) and size (1.4 vs. 1.2 mm, P=0.011) of tumors in the MAT group was elevated when compared with the control group. Tumor formation of the SECO group did not differ from the control group. Intake of MAT increased the level of both MAT and enterolactone in the plasma while SECO feeding increased SECO, enterodiol, and enterolactone (P=0.001). These results showed that MAT or SECO do not prevent intestinal carcinogenesis in Min mice and that MAT may have adverse effects. (c) 2005 Elsevier Ireland Ltd. All rights reserved.


colon cancer, matairesinol, Min mice, secoisolariciresinol

Last updated on 2019-09-12 at 03:58