A simple mass-action model for the eukaryotic heat shock response and its mathematical validation

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Petre I, Mizera A, Hyder CL, Meinander A, Mikhailov A, Morimoto RI, Sistonen L, Eriksson JE, Back RJ
Förläggare: SPRINGER
Publiceringsår: 2011
Tidskrift: Natural Computing
Tidskriftsakronym: NAT COMPUT
Volym: 10
Nummer: 1
Artikelns första sida, sidnummer: 595
Artikelns sista sida, sidnummer: 612
Antal sidor: 18
ISSN: 1567-7818
eISSN: 1572-9796


Abstrakt

The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides a useful foundation for modeling strategies of more complex cellular processes.


Nyckelord

Heat shock element, Heat shock factor, Heat shock protein, Heat shock response, Mathematical model, Regulatory network

Senast uppdaterad 2019-14-12 vid 05:10