A novel and efficient synthesis of highly oxidized lignans by a methyltrioxorhenium/hydrogen peroxide catalytic system. Studies on their apoptogenic and antioxidant activity

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Roberta Bernini, Giampiero Gualandi, Claudia Crestini, Maurizio Barontini, Maria Cristina Belfiore, Stefan Willför, Patrik Eklund, Raffaele Saladino
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication year: 2009
Journal: Bioorganic and Medicinal Chemistry
Journal acronym: BIOORGAN MED CHEM
Volume number: 17
Issue number: 15
Start page: 5676
End page: 5682
Number of pages: 7
ISSN: 0968-0896


Abstract

Highly oxidized lignans produced during the cytochrome P-450 metabolism in the cells show biological activities significantly different from those of their parent natural compounds. Lignans precursors of mammalian enterolignans were treated with a methyltrioxorhenium/hydrogen peroxide catalytic system to afford new compounds oxidized at benzylic as well as in arylic positions. The evaluation of the antioxidant and apoptogenic activity by in vivo protocols of these compounds showed some interesting structure-activity relationships related to the oxidation degree of the molecules. (C) 2009 Elsevier Ltd. All rights reserved.


Keywords

Antioxidant activity, Apoptogenic activity, Ethanol Oxidation, Lignans, Methyltrioxorhenium

Last updated on 2019-16-11 at 05:28