Synthesis and preclinical characterization of [Cu-64]NODAGA-MAL-exendin-4 with a N-epsilon-maleoyl-L-lysyl-glycine linkage

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Cheng-Bin Yim, Kirsi Mikkola, Veronica Fagerholm, Viki-Veikko Elomaa, Tamiko Ishizu, Johan Rajander, Joern Schlesinger, Anne Roivainen, Pirjo Nuutila, Olof Solin
Publisher: ELSEVIER SCIENCE INC
Publication year: 2013
Journal: Nuclear Medicine and Biology
Journal acronym: NUCL MED BIOL
Volume number: 40
Issue number: 8
Start page: 1006
End page: 1012
Number of pages: 7
ISSN: 0969-8051


Abstract

Conclusions: The incorporated MAL linkage in [Cu-64]NODAGA-MAL-exendin-4 was unable to reduce kidney radioactivity levels, compared to [Cu-64]NODAGA-exendin-4. The applicability of metabolizable linkages in the design of kidney-saving exendin-4 analogs requires further investigation. (C) 2013 Elsevier Inc. All rights reserved.


Keywords

Copper-64, Exendin, GLP-1 receptor, NODAGA, Renal brush border membrane

Last updated on 2019-16-09 at 08:22