Iron-Catalyzed Arylation of Aromatic Ketones and Aldehydes Mediated by Organosilanes

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Risto Savela, Marcin Majewski, Reko Leino
Förläggare: WILEY-V C H VERLAG GMBH
Publiceringsår: 2014
Tidskrift: European Journal of Organic Chemistry
Tidskriftsakronym: EUR J ORG CHEM
Nummer: 19
Artikelns första sida, sidnummer: 4137
Artikelns sista sida, sidnummer: 4147
Antal sidor: 11
ISSN: 1434-193X


Abstrakt

A simple and efficient iron-catalyzed method for arylation of aromatic carbonyl compounds is reported. The use of 4% FeCl3 or Fe(acac)(3) as the catalyst, in combination with a slight excess of chlorotrimethylsilane and triethylsilane, chlorination of benzylic ketones and aldehydes with subsequent Friedel-Crafts alkylation of arenes is achieved. Although the method is limited by the general constraints associated with Friedel-Crafts alkylation reactions, robust applications for the synthesis of pharmaceutical intermediates and so on can be envisioned.


Nyckelord

Homogeneous catalysis, Iron, Silanes, Synthetic methods

Senast uppdaterad 2019-05-12 vid 03:03