Iron-Catalyzed Arylation of Aromatic Ketones and Aldehydes Mediated by Organosilanes

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Risto Savela, Marcin Majewski, Reko Leino
Publisher: WILEY-V C H VERLAG GMBH
Publication year: 2014
Journal: European Journal of Organic Chemistry
Journal acronym: EUR J ORG CHEM
Issue number: 19
Start page: 4137
End page: 4147
Number of pages: 11
ISSN: 1434-193X


Abstract

A simple and efficient iron-catalyzed method for arylation of aromatic carbonyl compounds is reported. The use of 4% FeCl3 or Fe(acac)(3) as the catalyst, in combination with a slight excess of chlorotrimethylsilane and triethylsilane, chlorination of benzylic ketones and aldehydes with subsequent Friedel-Crafts alkylation of arenes is achieved. Although the method is limited by the general constraints associated with Friedel-Crafts alkylation reactions, robust applications for the synthesis of pharmaceutical intermediates and so on can be envisioned.


Keywords

Homogeneous catalysis, Iron, Silanes, Synthetic methods

Last updated on 2019-14-11 at 02:18