One-pot synthesis of (R)-2-acetoxy-1-indanone from 1,2-indanedione combining metal catalyzed hydrogenation and chemoenzymatic dynamic kinetic resolution

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Otto Långvik, Thomas Sandberg, Johan Wärnå, Dmitry Yu Murzin, Reko Leino
Publication year: 2015
Journal: Catalysis Science and Technology
Journal acronym: CATAL SCI TECHNOL
Volume number: 5
Issue number: 1
Start page: 150
End page: 160
Number of pages: 11
ISSN: 2044-4753
eISSN: 2044-4761


Combination of the regioselective hydrogenation of the prochiral diketone 1,2-indanedione with chemoenzymatic dynamic kinetic resolution of the resulting rac-2-hydroxy-1-indanone was investigated. A new simple to operate, one-pot reaction sequence provides the valuable building block (R)-2-acetoxy-1-indanone in moderate enantiopurity (86-92% ee) and a competitive isolated yield (39%) compared with a traditional isolated batch reaction approach.

Last updated on 2019-18-11 at 02:59