Dissolution patterns of biocompatible glasses in 2-amino-2-hydroxymethyl-propane-1,3-diol (Tris) buffer

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Fagerlund S, Hupa L, Hupa M
Publication year: 2013
Journal: Acta Biomaterialia
Journal acronym: ACTA BIOMATER
Volume number: 9
Issue number: 2
Start page: 5400
End page: 5410
Number of pages: 11
ISSN: 1742-7061


A continuous flow measurement system with sensitive on-line ion analysis has been applied to study the initial dissolution behaviour of biocompatible glasses in Tris. Altogether 16 glasses with widely varying compositions were studied. The measurement system allowed for quantitative determination of the time-dependent rates of dissolution of sodium, potassium, calcium, magnesium, silicon and phosphorus during the first 10-15 min in contact with Tris solution. The dissolution rates of the different ions showed significant glass to glass variations, but all glasses studied showed one of four distinct dissolution patterns. The ion dissolution rates after an exposure of 1000 s, expressed as the normalized surface-specific mass loss rates, were compared with the in vitro and in vivo reactivity of the glasses as predicted by models in the literature. The results showed a clear correlation between the dissolution rates of the glasses in Tris and their reactivity as measured by other different methods. Consequently, the measured short-term dissolution patterns could be used to determine which glasses are suitable as bioactive, biodegradable, or inert biomaterials for medical devices.


Biocompatible glass, Dissolution profile, Inductively coupled plasma, Ion release, Tris buffer

Last updated on 2020-24-02 at 05:31