Mesoporous silica nanoparticles facilitating the dissolution of poorly soluble drugs in orodispersible films

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Ṣen Karaman D, Patrignani G, Rosqvist E, Smått J, Orłowska A, Mustafa R, Preis M, Rosenholm JM
Förläggare: Elsevier
Publiceringsår: 2018
Tidskrift: European Journal of Pharmaceutical Sciences
Volym: 122
Artikelns första sida, sidnummer: 152
Artikelns sista sida, sidnummer: 159
ISSN: 0928-0987


Abstrakt

Orodispersible films (ODF) are immediately dissolving/disintegrating intraoral dosage forms,
presented as substitutes of conventional tablets or capsules to ease
problems associated with swallowing. Efforts have been made to be able
to exploit ODFs as dosage forms for poorly soluble drugs. In the last
two decades, mesoporous silica nanoparticles
(MSNs) have been extensively used in drug delivery applications to
overcome solubility problems of drugs. The tunable features of MSNs make
them suitable candidates as drug carriers and solubility enhancers. In
this study, the feasibility of MSNs as a carrier of poorly soluble
drugs, using prednisolone as a model drug, in ODFs was investigated. Our
results revealed that the increased amount of MSNs in ODFs leads to
shortening of the disintegration time of the films. Drug content
investigations showed that low dose ODFs with prednisolone incorporation
efficiencies higher than 80% could be produced. Furthermore, the
prednisolone release profile from ODFs can be tuned with the
incorporation of MSNs as drug carrier (MSNpred). The MSNpred
incorporated ODFs yield with immediate release of drug from the ODF,
whereby 90% of the prednisolone content could be released in the first
minutes. By modifying the MSNpred design with copolymer surface coating, prednisolone (cop-MSNpred) release can be modulated into a two-step sustained release
profile. To sum up, the MSNs platform does not only provide careful low
dose incorporation into ODF with high efficiency, but it also aids in
tuning the drug release profiles from ODFs.


Nyckelord

mesoporous silica nanoparticles, Orodispersible films, Poorly soluble drugs, Solvent casting


Dokument


Senast uppdaterad 2020-02-04 vid 08:54