Enantioselective hydrogenation of ethyl benzoylformate, from mechanism and kinetics to continuous reactor technology

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Gerson Martin, Päivi Mäki-Arvela, Johan Wärnå, Dmitry Yu. Murzin, Tapio Salmi
Publication year: 2014
Journal: Topics in Catalysis
Volume number: 57
Issue number: 17-20
Start page: 1576
End page: 1581


The enantioselective hydrogenation of ethyl benzoylformate over (−)-cinchonidine (CD)-modified Pt/Al2O3 catalyst in semi-batch and continuous fixed bed reactors was studied as a function of the modifier concentration and reaction temperature. The kinetic results from the semibatch reactor showed a higher enantioselectivity and lower initial rate as the amount of modifier was increased. The results from the fixed bed reactor demonstrates that continuous enantioselective hydrogenation is possible and that continuous feeding of (−)-CD is needed to maintain a high steady-state enantioselectivity.

Last updated on 2019-07-12 at 03:33