Two-step synthesis of monoterpenoid dioxinols exhibiting analgesic activity from isopulegol and benzaldehyde over heterogeneous catalysts

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Martina Stekrova, Päivi Mäki-Arvela, Ewelina Leino, Karolina M. Valkaj, Kari Eränen, Atte Aho, Annika Smeds, Narendra Kumar, Konstantin P. Volcho, Nariman F. Salakhutdinov, Dmitry Yu. Murzin
Publiceringsår: 2017
Tidskrift: Catalysis Today
Volym: 279, Part 1
Artikelns första sida, sidnummer: 56
Artikelns sista sida, sidnummer: 62
eISSN: 1873-4308


Abstrakt

Benzodioxinols, compounds with 6-membered heterocycles containing two oxygen atoms, exhibit promising analgesic activity. In the current study, synthesis of dioxinol via two-step approach including Prins cyclization of isopulegol with benzaldehyde to tetrahydropyran and its ring-rearrangement to dioxinol was investigated. Different acidic and basic catalysts were studied in the second step and the highest selectivity toward dioxinol was achieved using mesoporous Ce-composite material.


Nyckelord

engineering education

Senast uppdaterad 2019-19-10 vid 05:01