Fabrication of drug-loaded edible carrier substrates from nanosuspensions by flexographic printing

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

Interna författare/redaktörer

Publikationens författare: Palo M, Kolakovic R, Laaksonen T, Määttänen A, Genina N, Salonen J, Peltonen J, Sandler N
Förläggare: Elsevier BV
Publiceringsår: 2015
Tidskrift: International Journal of Pharmaceutics
Tidskriftsakronym: Int.J.Pharm.
Volym: 494
Nummer: 2
Artikelns första sida, sidnummer: 603
Artikelns sista sida, sidnummer: 610
ISSN: 0378-5173
eISSN: 1873-3476


The main goal of the current work was to investigate the possible use of flexographic printing for the conversion of nanosuspensions into solid dosage forms. Aqueous nanosuspensions of indomethacin (IND) and itraconazole (ITR) with Poloxamer 407 as the stabilizer agent were prepared by wet ball-milling. The nanosuspensions were flexographically printed on three different substrates, including two commercially available edible substrates. The printed formulations were characterized with X-ray diffractometry (XRD) and scanning electron microscopy (SEM). In addition, dissolution studies for the printed IND and ITR formulations were conducted. The mean particle size of milled nanosuspensions of IND and ITR was 422.6 ± 7.7 nm and 698.1 ± 14.0 nm, respectively. The SEM imaging showed even distribution of nanosuspensions on the substrates after printing without any evident agglomeration. The printed formulations contained drug at least partially in crystalline form. The drug dissolution rate from the prepared formulations was improved compared to the pure drug. The drug release from the preparations on edible substrates was slightly slower due to the incorporation of the drug particles into the substrate matrix. In conclusion, the results indicated that flexographic printing can be considered as a promising fabrication method of solid nanoparticulate systems with enhanced dissolution behavior.


Ball-milling, Flexographic printing, Indomethacin, Itraconazole, Nanoparticles

Senast uppdaterad 2020-25-02 vid 03:13