Solid-State Properties and Controlled Release of Ranitidine Hydrochloride from Tailored
Oxidised Cellulose Beads

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Jani Trygg, Emrah Yildir, Ruzica Kolakovic, Niklas Sandler, Pedro Fardim
Publisher: WILEY-V C H VERLAG GMBH
Publication year: 2015
Journal: Macromolecular Materials and Engineering
Volume number: 300
Issue number: 2
Start page: 210
End page: 217
eISSN: 1439-2054


Abstract

Oxidised cellulose beads (anionic groups 0.1–1.85mmolg1) were loaded with ranitidine HCl. Polymorphic form and crystallinity of the drug was assessed by calorimetric and spectrometric techniques. Release profiles were obtained at physiological conditions and fitted to suitable mathematical models to gain an understanding on release mechanism. Solid-state analysis showed that the drug was solidified in amorphous form. The amount of drug was uniform and increased with charge of the beads upto loading degree of 25.8%. Release profiles fitted well to the Baker-Lonsdale’s model for non-swelling system indicating open structure for freely soluble drug. The release was pH independent, providing fast release already at pH 1.2 in simulated gastrointestinal track.


Keywords

amorphous drug, drug delivery, oxidised celluolse beads, swelling, uniformity of content

Last updated on 2019-17-09 at 07:50