Comparative safety evaluation of silica-based particles

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Kettiger H, Karaman DS, Schiesser L, Rosenholm JM, Huwyler J
Publisher: Pergamon
Publication year: 2015
Journal: Toxicology in Vitro
Volume number: 30
Issue number: 1
Start page: 355
End page: 363
ISSN: 0887-2333
eISSN: 1879-3177


Abstract

Silica nanoparticles (SNPs) are increasingly used as drug delivery systems (DDS) and for biomedical imaging. Therapeutic and diagnostic agents can be incorporated into the silica matrix to improve the stability and dissolution of drug substances in biological systems. However, the safety of SNPs as drug carriers remains controversial. To date, no validated and accepted nano-specific tests exist to predict the potentially harmful impact of these materials on the human body.

Last updated on 2019-21-08 at 07:37