Nanodiamond-Based Composite Structures for Biomedical Imaging and Drug Delivery

A2 Review article, Literature review, Systematic review


Internal Authors/Editors


Publication Details

List of Authors: Jessica M. Rosenholm, Igor I. Vlasov, Sergey A. Burikov, Tatiana A. Dolenko, Olga A. Shenderova
Publisher: American Scientific Publishers
Publication year: 2015
Journal: Journal of Nanoscience and Nanotechnology
Journal acronym: JNN
Volume number: 15
Issue number: 2
Start page: 959
End page: 971
eISSN: 1533-4899


Abstract

Nanodiamond particles are widely recognized candidates for biomedical applications due to their excellent biocompatibility, bright photoluminescence based on color centers and outstanding photostability. Recently, more complex architectures with a nanodiamond core and an external shell or nanostructure which provides synergistic benefits have been developed, and their feasibility for biomedical applications has been demonstrated. This review is aimed at summarizing recent achievements in the fabrication and functional demonstrations of nanodiamond-based composite structures, along with critical considerations that should be taken into account in the design of such structures from a biomedical point of view. A particular focus of the review is core/shell structures of nanodiamond surrounded by porous silica shells, which demonstrate a remarkable increase in drug loading efficiency; as well as nanodiamonds decorated with carbon dots, which have excellent potential as bioimaging probes. Other combinations are also considered, relying on the discussed inherent properties of the inorganic materials being integrated in a way to advance inorganic nanomedicine in the quest for better health-related nanotechnology.


Keywords

biomedical imaging, carbon nanostructures, Core-shell, drug delivery, mesoporous silica, nanodiamonds

Last updated on 2019-16-12 at 04:53