Keratins in health and disease

A2 Granskningsartikel, litteraturgranskning, systematisk granskning


Interna författare/redaktörer


Publikationens författare: TOIVOLA D.M., BOOR P., ALAM C., STRNAD P
Förläggare: Elsevier Ltd
Publiceringsår: 2015
Tidskrift: Current Opinion in Cell Biology
Volym: 32
Artikelns första sida, sidnummer: 73
Artikelns sista sida, sidnummer: 81
eISSN: 1879-0410


Abstrakt

The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and their inherited and spontaneous mutations give rise to keratinopathies. For example, mutations in K1/K5/K10/K14 cause epidermal skin diseases whereas simple epithelial K8/K18/K19 variants predispose to development of several liver disorders. Due to their abundance, tissue- and context-specific expression, keratins constitute excellent diagnostic markers of both neoplastic and non-neoplastic diseases. During injury and in disease, keratin expression levels, cellular localization or posttranslational modifications are altered. Accumulating evidence suggests that these changes modulate multiple processes including cell migration, tumor growth/metastasis and development of infections. Therefore, our understanding of keratins is shifting from diagnostic markers to active disease modifiers.


Nyckelord

disease, human mutations, keratin

Senast uppdaterad 2019-06-12 vid 05:02