Associate professor

Diana Toivola

Senior Lecturer, Cell Biology
Biträdande professor, Cell Biology
Email: diana.toivola@abo.fi
Mobile: +358-504007732
Phone: +358-2-2154092


Peer-reviewed publications

A1 Journal article (refereed)
Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes (2018)
ALAM C.M., SILVANDER J.S.G., HELENIUS T.O., TOIVOLA D.M.
Acta Physiologica
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A1 Journal article (refereed)
Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway (2017)
Lähdeniemi IAK, Misiorek JO, Antila CJM, Landor S, Stenvall C-G, Fortelius LE, Bergström LK, Sahlgren C & Toivola DM
Cell Death and Differentiation
British Journal of Pharmacology
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A1 Journal article (refereed)
Keratins regulate β-cell mitochondrial morphology, motility, and homeostasis (2017)
Silvander JSG, Kvarnström SM, Kumari-Ilieva A, Shrestha A, Alam CM, Toivola DM
FASEB Journal
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A2 Review article, Literature review, Systematic review
Tailored approaches in drug development and diagnostics: from molecular design to biological model systems (2017)
Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A. Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi M. H. Salo-Ahen, Ronald Österbacka, John E. Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler
Advanced Healthcare Materials
Molecular Therapy
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A1 Journal article (refereed)
Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway (2016)
Julia O. Misiorek, Iris A.K. Lähdeniemi, Joel H. Nyström, Valeriy M. Paramonov, Josef A. Gullmets, Helena Saarento, Adolfo Rivero-Müller, Trine Husøy, Pekka Taimen, Diana M. Toivola
Carcinogenesis
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A1 Journal article (refereed)
Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon (2016)
Muhammad Nadeem Asghar, Shubha Priyamvada, Joel H. Nyström, Arivarasu Natarajan Anbazhagan, Pradeep K. Dudeja, Diana M Toivola
AJP - Gastrointestinal and Liver Physiology
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A1 Journal article (refereed)
Keratins are altered in intestinal disease-related stress responses (2016)
Helenius TO, Antman CA, Asghar MN, Nyström JH, Toivola DM
Cells
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A2 Review article, Literature review, Systematic review
Simple Epithelial Keratins (2016)
Strnad P, Guldiken N, Helenius T, Misiorek J, Nyström J, Lähdeniemi I, Silvander J, Kuscuoglu D, Toivola D
Methods in Enzymology
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A1 Journal article (refereed)
Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles (2016)
Desai D, Prabhakar N, Mamaeva V, Şen Karaman D, Lähdeniemi IAK, Sahlgren C, Rosenholm JM, Toivola DM
International Journal of Nanomedicine
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A1 Journal article (refereed)
Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice (2015)
TOIVOLA D.M., HABTEZION A., MISIOREK J.O., ZHANG L.X., NYSTRÖM J.H., SHARPE O., ROBINSON W.H., KWAN R., OMARY M.B.
FASEB Journal
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A1 Journal article (refereed)
Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism (2015)
HELENIUS T.O., MISIOREK J.O., NYSTRÖM J.H., FORTELIUS L.E., HABTEZION A., LIAO J., ASGHAR M.N., ZHANG H., AZHAR S., OMARY M.B., TOIVOLA D.M.
Molecular biology of the cell
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A2 Review article, Literature review, Systematic review
Keratins in health and disease (2015)
TOIVOLA D.M., BOOR P., ALAM C., STRNAD P
Current Opinion in Cell Biology
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A1 Journal article (refereed)
The amount of keratins matters for stress protection of the colonic epithelium (2015)
ASGHAR M.N., SILVANDER J.S.G., HELENIUS T.O., LÄHDENIEMI I.A.K., ALAM C., FORTELIUS L.E., HOLMSTEN R.O., TOIVOLA D.M.
PLoS ONE
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A1 Journal article (refereed)
Design considerations for mesoporous silica nanoparticulate systems in facilitating biomedical applications (2014)
Diti Desai, Didem Sen Karaman, Neeraj Prabhakar, Sina Tadayon, Alain Duchanoy, Diana M. Toivola, Sadhana Rajput, Tuomas Näreoja, Jessica M. Rosenholm
Mesoporous Biomaterials
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A1 Journal article (refereed)
In vivo imaging of reactive oxygen and nitrogen species in murine colitis (2014)
Asghar MN, Emani R, Alam C, Helenius TO, Grönroos TJ, Sareila O, Din MU, Holmdahl R, Hänninen A, Toivola DM
Inflammatory Bowel Diseases
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A1 Journal article (refereed)
On the non-linear attachment characteristics of blood to bacterial cellulose/kaolin biomaterials (2014)
Diosángeles Soto Véliz, Catharina Alam, Diana M. Toivola, Martti Toivakka, Parvez Alam
Colloids and Surfaces B: Biointerfaces
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A1 Journal article (refereed)
Bacterial cellulose–kaolin nanocomposites for application as biomedical wound healing materials (2013)
Dwi Wanna, Catharina Alam, Diana M Toivola, Parvez Alam
Advances in Natural Sciences: Nanoscience and Nanotechnology
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A1 Journal article (refereed)
Casein hydrolysate diet controls intestinal T cell activation, free radical production and microbial colonisation in NOD mice (2013)
Emani R, Asghar MN, Toivonen R, Lauren L, Söderström M, Toivola DM, van Tol EAF, Hänninen A
Diabetologia
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A1 Journal article (refereed)
Keratin 8 modulates β-cell stress responses and normoglycaemia (2013)
Catharina M. Alam, Jonas S. G. Silvander, Ebot N. Daniel, Guo-Zhong Tao, Sofie M. Kvarnström, Parvez Alam, M. Bishr Omary, Arno Hänninen, Diana M. Toivola
Journal of Cell Science
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A1 Journal article (refereed)
Comparative Cellular Toxicity of Hydrophilic and Hydrophobic Microcystins on Caco-2 Cells (2012)
Vesterkvist PSM, Misiorek JO, Spoof LEM, Toivola DM, Meriluoto JAO
Toxins
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A1 Journal article (refereed)
Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization (2012)
Karaman, Desai, Senthilkumar, Johansson, Råtts, Odén, Eriksson, Sahlgren, Toivola, Rosenholm
Nanoscale Research Letters
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A1 Journal article (refereed)
Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon (2011)
Habtezion A, Toivola DM, Asghar MN, Kronmal GS, Brooks JD, Butcher EC, Omary MB
Proceedings of the National Academy of Sciences
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A1 Journal article (refereed)
Adrenoceptor activity of muscarinic toxins identified from mamba venoms (2011)
Näreoja K, Kukkonen JP, Rondinelli S, Toivola DM, Meriluoto J, Näsman J
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A1 Journal article (refereed)
Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer (2011)
Veronika Mamaeva, Jessica M Rosenholm, Laurel Tabe Bate-Eya, Lotta Bergman, Emilia Peuhu , Alain Duchanoy, Lina E. Fortelius, Sebastian Landor, Diana M Toivola, Mika Lindén and Cecilia Sahlgren
A2 Review article, Literature review, Systematic review
Intermediate filaments take the heat as stress proteins (2010)
Toivola DM, Strnad P, Habtezion A, Omary MB
Trends in Cell Biology
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A2 Review article, Literature review, Systematic review
Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis (2009)
Tao GZ, Looi KS, Toivola DM, Strnad P, Zhou Q, Liao J, Wei YQ, Habtezion A, Omary MB
Journal of Cell Science
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A1 Journal article (refereed)
Keratins provide virus-dependent protection or predisposition to injury in coxsackievirus-induced pancreatitis (2009)
DM Toivola, SE Ostrowski, H Baribault, TM Magin, AI Ramsingh, MB Omary
Cell Health and Cytoskeleton
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A1 Journal article (refereed)
Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion (2008)
Harada M, Strnad P, Toivola DM, Omary MB
Experimental Cell Research
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A1 Journal article (refereed)
Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models (2008)
Strnad P, Tao GZ, Zhou Q, Harada M, Toivola DM, Brunt EM, Omary B
Gastroenterology
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A1 Journal article (refereed)
Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury (2008)
Toivola DM, Nakamichi I, Strnad P, Michie SA, Ghori N, Harada M, Zeh K, Oshima RG, Baribault H, Omary MB
American Journal of Pathology
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A1 Journal article (refereed)
Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation (2008)
Tao GZ, Li DH, Zhou Q, Toivola DM, Strnad P, Sandesara N, Cheung RC, Hong A, Omary MB
Journal of Pathology
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A1 Journal article (refereed)
Phosphorylation-dependent interaction of intermediate filament keratins with non-muscle myosin II-C in human colonic epithelial cells (2008)
Tao GZ, Toivola DM, Zhou Q, Tao Y, Omary B
Gastroenterology
A1 Journal article (refereed)
Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization (2007)
Stone MR, O'Neill A, Lovering RM, Strong J, Resneck WG, Reed PW, Toivola DM, Ursitti JA, Omary MB, Bloch RJ
Journal of Cell Science
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A1 Journal article (refereed)
Colonic hyperplasia in keratin 8-null mice is mediated by resistance to apoptosis and presence of luminal microflora (2007)
Habtezion A, Toivola D, Brooks J, Kronmal GS, Butcher E, Omary B
Gastroenterology
A2 Review article, Literature review, Systematic review
From Mallory to Mallory-Denk bodies: what, how and why? (2007)
Zatloukal K, French SW, Stumptner C, Strnad P, Harada M, Toivola DM, Cadrin M, Omary MB
Experimental Cell Research
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A1 Journal article (refereed)
Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation (2007)
Zhong BH, Strnad P, Toivola DM, Tao GZ, Ji XH, Greenberg HB, Omary MB
Molecular biology of the cell
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A1 Journal article (refereed)
'Heads and tails' of intermediate filament phosphorylation: multiple sites and functional insights (2006)
Omary MB, Ku NO, Tao GZ, Toivola DM, Liao J
Trends in Biochemical Sciences
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A1 Journal article (refereed)
Keratins modulate mitochondrial HMG-CoA synthase in the colon (2006)
Toivola DM, Habtezion A, Liao J, Zhou Q, Butcher EC, Omary MB
Gastroenterology
A1 Journal article (refereed)
Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation (2006)
Strnad P, Siegel M, Toivola DM, Choi K, Kosek JC, Khosla C, Omary MB
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A1 Journal article (refereed)
Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner (2006)
Tao GZ, Toivola DM, Zhou Q, Strnad P, Xu BH, Michie SA, Omary MB
Journal of Cell Science
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A1 Journal article (refereed)
Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments (2005)
Toivola DM, Tao GZ, Habtezion A, Liao J, Omary MB
Trends in Cell Biology
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A1 Journal article (refereed)
Conjugated but not unconjugated bile acids induce time-dependent increases in proliferation in Barrett's esophagus ex vivo cultures. (2005)
Siersema PD, Kaur BS, Toivola DM, Hofmann AF, Omary MB, Kuipers EJ, Triadafilopoulos G
European Journal of Gastroenterology and Hepatology
A1 Journal article (refereed)
Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment (2005)
Habtezion A, Toivola DM, Butcher EC, Omary MB
Journal of Cell Science
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A1 Journal article (refereed)
Keratin 8 overexpression promotes mouse Mallory body formation (2005)
Nakamichi I, Toivola DM, Strnad P, Michie SA, Oshima RG, Baribault H, Omary MB
Journal of Cell Biology
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A1 Journal article (refereed)
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease (2004)
Toivola DA, Ku NO, Resurreccion EZ, Nelson DR, Wright TL, Omary MB
Hepatology
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A1 Journal article (refereed)
Keratins modulate colonocyte electrolyte transport via protein mistargeting (2004)
Toivola DM, Krishnan S, Binder HJ, Singh SK, Omary MB
Journal of Cell Biology
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A1 Journal article (refereed)
Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappa B activation (2004)
Zhong BH, Zhou Q, Toivola DM, Tao GZ, Resurreccion EZ, Omary MB
Journal of Cell Science
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A1 Journal article (refereed)
Studying simple epithelial keratins in cells and tissues (2004)
Ku NO, Toivola DM, Zhou Q, Tao GZ, Zhong BH, Omary MB
Methods in Cell Biology
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A1 Journal article (refereed)
Keratin 20 helps maintain intermediate filament organization in intestinal epithelia (2003)
Zhou Q, Toivola DM, Feng NG, Greenberg HB, Franke WW, Omary MB
Molecular biology of the cell
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A1 Journal article (refereed)
Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury (2003)
Tao GZ, Toivola DM, Zhong BH, Michie SA, Resurreccion EZ, Tamai Y, Taketo MM, Omary MB
Journal of Cell Science
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A1 Journal article (refereed)
Keratins: Guardians of the liver (2002)
Omary MB, Ku NO, Toivola DM
Hepatology
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A1 Journal article (refereed)
Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells (2002)
Toivola DM, Zhou Q, English LS, Omary MB
Molecular biology of the cell
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A1 Journal article (refereed)
Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18 (2001)
Toivola DM, Nieminen MI, Hesse M, He T, Baribault H, Magin TM, Omary MB, Eriksson JE
Hepatology
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A1 Journal article (refereed)
Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injury (2000)
Toivola DM, Ku NO, Ghori N, Lowe AW, Michie SA, Omary MB
Experimental Cell Research
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A1 Journal article (refereed)
Simple epithelial keratins are dispensable for cytoprotection in two pancreatitis models (2000)
Toivola DM, Baribault H, Magin T, Michie SA, Omary MB
AJP - Gastrointestinal and Liver Physiology
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A2 Review article, Literature review, Systematic review
The cytoskeleton of digestive epithelia in health and disease (1999)
Ku NO, Zhou XJ, Toivola DM, Omary MB
AJP - Gastrointestinal and Liver Physiology
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A1 Journal article (refereed)
Toxins affecting cell signalling and alteration of cytoskeletal structure (1999)
Toivola, Eriksson
Toxicology in Vitro
A1 Journal article (refereed)
Strategies to assess phosphoprotein phosphatase and protein kinase-mediated regulation of the cytoskeleton (1998)
Eriksson, Toivola, Sahlgren, Mikhailov, Härmälä-Braskén
Methods in Enzymology
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A1 Journal article (refereed)
Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments (1997)
Toivola, Goldman, Garrod, Eriksson
Journal of Cell Science
A1 Journal article (refereed)
Choosing analytical strategy for microcystins (1996)
Jussi Meriluoto, Ann-Sofi Härmälä-Braskén, John Eriksson, Diana Toivola, Tore Lindholm
Phycologia
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A1 Journal article (refereed)
Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates (1994)
Toivola DM, Eriksson JE, Brautigan DL
FEBS Letters
A4 Conference proceedings
Testing of Toxicity in Cyanobacteria by Cellular Assays (1994)
J. E. Eriksson, D. M. Toivola, M. Reinikainen, C. M. I. Råbergh, J. A. O. Meriluoto
Woodhead Publishing Limited
A1 Journal article (refereed)
Effects of the phospholipid environment in the plasma membrane on receptor interaction with the adenylyl cyclase complex of intact cells. (1993)
Christian Jansson, Ann-Sofi Härmälä, Diana M. Toivola, Peter Slotte
BBA - Biochimica et Biophysica Acta
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A1 Journal article (refereed)
ANOMALOUS DOSE-RESPONSE RELATIONSHIP DUE TO ASSOCIATION COLLOIDAL BEHAVIOUR OF SOLUBLE AMPHIPHILIC COMPOUNDS (1991)
ISOMAA B, HÄGERSTRAND H, TOIVOLA D
Alternatives to Laboratory Animals
A1 Journal article (refereed)
EFFECTS OF DEHYDROABIETIC ACID ON THE ERYTHROCYTE MEMBRANE (1991)
TOIVOLA DM, ISOMAA B
Chemico-Biological Interactions
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A1 Journal article (refereed)
MORPHOLOGICAL CHANGES AND CYTOTOXICITY IN ISOLATED HEPATOCYTES (1991)
TOIVOLA D, ERIKSSON JE
Alternatives to Laboratory Animals
A1 Journal article (refereed)
Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases (1990)
Eriksson JE, Toivola D, Meriluoto JA, Karaki H, Han YG, Hartshorne D
Biochemical and Biophysical Research Communications


Other publications

F1 Published independent work of art
Undrans Mosaik. Cantata celebrating Åbo Akademi 100 years. First Performance, Vaasa Church. Florakören, Brahe Djäknar, Pedavoces, Soloists 17.3.2018 (2018)
Salla Tuori, Nina Kivinen, Diana Toivola, Ulf Långbacka, Daniel Siegel, Sven Olav Back
O2 Other
Decreased susceptibility to eccentric injury in muscles lacking cytokeratin 8 (2004)
Lovering RM, O'Neil AM, Stone MR, Toivola DM, Omary MB, De Deyne PG, Bloch RJ
FASEB Journal
O2 Other
Keratin 8 and 18 overexpression is not a prerequisite for Mallory body formation and pancreatic injury (2004)
Nakamichi I, Toivola DM, Michie SA, Baribault H, Oshima RG, Omary MB
Molecular biology of the cell
O2 Other
Keratin hyperphosphorylation as a marker of cirrhosis and chronic hepatitis C (2002)
Toivola DM, Ku NO, Resurreccion EZ, Nelson DR, Wright TL, Omary M
Gastroenterology
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O2 Other
CHARACTERIZATION OF THE IN-VIVO PHOSPHORYLATION OF LIVER KERATIN-8 AND KERATIN-18 (1995)
TOIVOLA DM, MIKHAILOV A, GOLDMAN RD, ERIKSSON JE
Molecular biology of the cell
D4 Published development or research report or study
Undersökning av förekomsten av toxiska blågrönalger i Långsjön och Markusbölefjärden (1989)
Diana Toivola, Jussi Meriluoto, John Eriksson
D4 Published development or research report or study
Förekomsten av toxiska blågrönalger i Åländska insjöar (1988)
Diana Toivola, John Eriksson, Jussi Meriluoto

Last updated on 2019-29-01 at 14:13

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