Cecilia Sahlgren

Professor, Cell Biology
Email: cecilia.sahlgren@abo.fi
Mobile: +358-503009680
Phone: +358-2-2153300


Peer-reviewed publications

A1 Journal article (refereed)
Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells. (2019)
Ulrika Wilhelmsson, Isabell Lebkuechner, Renata Leke, Pavel Marasek, Xiaoguang Yang, Daniel Antfolk, Meng Chen, Paria Mohseni, Eva Lasič, Saša Trkov Bobnar, Matjaž Stenovec, Robert Zorec, Andras Nagy, Cecilia Sahlgren, Marcela Pekna, Milos Pekny
Cerebral Cortex
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A1 Journal article (refereed)
A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions (2018)
Nicole C. A. van Engeland, Andreas M. A. O. Pollet, Jaap M. J. den Toonder, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren
Lab on a Chip
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A1 Journal article (refereed)
Mapping of the three-dimensional lymphatic microvasculature in bladder tumours using light-sheet microscopy (2018)
Nobuyuki Tanaka, Dagmara Kaczynska, Shigeaki Kanatani, Cecilia Sahlgren, Przemysław Mitura, Andrzej Stepulak, Ayako Miyakawa, Peter Wiklund, Per Uhlén
British Journal of Cancer
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A1 Journal article (refereed)
MDA-MB-231 Breast Cancer Cells and Their CSC Population Migrate Towards Low Oxygen in a Microfluidic Gradient Device (2018)
Sleeboom JJF, den Toonder JMJ, Sahlgren CM
International Journal of Molecular Sciences
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A1 Journal article (refereed)
Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis (2018)
Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Proceedings of the National Academy of Sciences
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A1 Journal article (refereed)
Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches (2018)
Sleeboom JJF, Amirabadi HE, Nair P, Sahlgren CM, den Toonder JMJ
Disease Models and Mechanisms
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A1 Journal article (refereed)
Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips (2018)
W. F. Quirós-Solano, N. Gaio, O. M. J. A. Stassen, Y. B. Arik, C. Silvestri, N. C. A. Van Engeland, A. Van der Meer, R. Passier, C. M. Sahlgren, C. V. C. Bouten, A. van den Berg, R. Dekker, P. M. Sarro
Scientific Reports
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A1 Journal article (refereed)
Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types (2018)
Mutvei AP, Landor SKJ, Fox R, Braune EB, Tsoi YL, Phoon YP, Sahlgren C, Hartman J, Bergh J, Jin SB, Lendahl U
Oncogene
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A1 Journal article (refereed)
Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1 (2018)
Driessen RCH, Stassen OMJA, Sjöqvist M, Rodriguez FS, Grolleman J, Bouten CVC, Sahlgren CM
Integrative Biology
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A1 Journal article (refereed)
Spatial patterning of the Notch ligand Dll4 controls endothelial sprouting in vitro (2018)
Tiemeijer LA, Frimat JP, Stassen OMJA, Bouten CVC, Sahlgren CM
Scientific Reports
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A1 Journal article (refereed)
Sumoylation of Notch1 represses its target gene expression during cell stress (2018)
Christian JM Antila, Vilma Rraklli, Henri A Blomster, Käthe M Dahlström, Tiina A Salminen, Johan Holmberg, Lea Sistonen, Cecilia Sahlgren
Cell Death and Differentiation
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A1 Journal article (refereed)
Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home? (2018)
Paramonov V, Desai D, Kettiger H, Mamaeva V, Rosenholm J, Sahlgren C, Rivero-Müller A
Nanotheranostics
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A1 Journal article (refereed)
Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface-functionalization controlled penetrance of biological membranes (2017)
Paatero I, Casals E, Niemi R, Özliseli E, Rosenholm JM, Sahlgren C
Scientific Reports
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A2 Review article, Literature review, Systematic review
Cardiac progenitor cells and the interplay with their microenvironment (2017)
Arianna Mauretti,Sergio Spaans, Noortje A. M. Bax, Cecilia Sahlgren, and Carlijn V. C. Bouten
Stem Cells International
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A1 Journal article (refereed)
Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway (2017)
Lähdeniemi IAK, Misiorek JO, Antila CJM, Landor S, Stenvall C-G, Fortelius LE, Bergström LK, Sahlgren C & Toivola DM
Cell Death and Differentiation
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A1 Journal article (refereed)
Selective regulation of Notch ligands during angiogenesis is mediated by vimentin (2017)
Daniel Antfolk, Marika Sjöqvist, Fang Cheng, Kimmo Isoniemi, Camille L. Duran, Adolfo Rivero-Muller, Christian Antila , Rasmus Niemi , Sebastian Landor, Carlijn V.C. Bouten, Kayla J. Bayless, John E. Eriksson, Cecilia Maria Sahlgren
Proceedings of the National Academy of Sciences
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A1 Journal article (refereed)
Spheroid three-dimensional culture enhances Notch signaling in cardiac progenitor cells (2017)
Arianna Mauretti, Fabrizio Rossi, Noortje A. M. Bax, Carmen Miano, Fabio Miraldi, Marie José Goumans, Elisa Messina, Alessandro Giacomello, Carlijn V. C. Bouten, Cecilia Sahlgren
MRS Communications
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A2 Review article, Literature review, Systematic review
Tailored approaches in drug development and diagnostics: from molecular design to biological model systems (2017)
Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A. Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi M. H. Salo-Ahen, Ronald Österbacka, John E. Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler
Advanced Healthcare Materials
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A1 Journal article (refereed)
Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity (2017)
Nobuyuki Tanaka, Shigeaki Kanatani, Raju Tomer, Cecilia Sahlgren, Pauliina Kronqvist, Dagmara Kaczynska, Lauri Louhivuori, Lorand Kis, Claes Lindh, Przemysław Mitura, Andrzej Stepulak, Sara Corvigno, Johan Hartman, Patrick Micke, Artur Mezheyeuski, Carina Strell, Joseph W. Carlson, Carlos Fernández Moro, Hanna Dahlstrand, Arne Östman, Kazuhiro Matsumoto, Peter Wiklund, Mototsugu Oya, Ayako Miyakawa, Karl Deisseroth, Per Uhlén
Nature Biomedical Engineering
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A1 Journal article (refereed)
Cardiomyocyte progenitor cell mechanoresponse unrevealed: strain avoidance and mechanosome development
(2016)
Arianna Mauretti, Noortje A. M. Bax, Mieke H. van Marion, Marie José Goumans, Cecilia Sahlgren, Carlijn V. C. Bouten
Integrative Biology
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A1 Journal article (refereed)
Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier (2016)
Habib Baghirov, Didem Karaman, Tapani Viitala, Alain Duchanoy, Yan-Ru Lou, Veronika Mamaeva, Evgeny Pryazhnikov, Leonard Khiroug, Catharina de Lange Davies, Cecilia Sahlgren, Jessica M. Rosenholm

PLoS ONE
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A1 Journal article (refereed)
Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying γ-secretase Inhibitors (2016)
Veronika Mamaeva, Rasmus Niemi, Michaela Beck, Ezgi Özliseli, Diti Desai, Sebastian Landor, Tove Gronroos, Pauliina Kronqvist, Ina K N Pettersen, Emmet McCormack, Jessica M Rosenholm, Mika Linden, Cecilia Sahlgren
Molecular Therapy
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A1 Journal article (refereed)
Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells (2016)
Eike-Benjamin Braune, Yat Long Tsoi, Yee Peng Phoon, Sebastian Landor, Helena Silva Cascales, Daniel Ramsköld, Qiaolin Deng, Arne Lindqvist, Xiaojun Lian, Cecilia Sahlgren, Shao-Bo Jin, Urban Lendahl
Stem Cell Reports
A4 Conference proceedings
Mesoporous silica nanoparticles for somatostatin targeted Notch activation in animal model of pancreatic neuroendocrine cancer (2016)
Paramonov VM, Desai D, Mamaeva V, Rosenholm J, Rivero-Muller A, Sahlgren C
Endocrine abstracts
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A2 Review article, Literature review, Systematic review
Mesoporous silica nanoparticles in tissue engineering – a perspective (2016)
Jessica Maria Rosenholm, Jixi Zhang, Mika Linden, Cecilia Sahlgren
Nanomedicine
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A1 Journal article (refereed)
Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells (2016)
Niina M. Santio, Sebastian K.-J. Landor, Laura Vahtera, Jani Ylä-Pelto, Elina Paloniemi, Susumu Y. Imanishi, Garry Corthals, Markku Varjosalo, Ganesh Babu Manoharan, Asko Uri, Urban Lendahl, Cecilia Sahlgren, Päivi J. Koskinen
Oncotarget
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A1 Journal article (refereed)
Prolonged Dye Release from Mesoporous Silica-Based Imaging Probes Facilitates Long-Term Optical Tracking of Cell Populations In Vivo (2016)
Jessica M. Rosenholm, Tina Gulin-Sarfraz, Veronika Mamaeva, Rasmus Niemi, Ezgi Özliseli, Diti Desai, Daniel Antfolk, Eva von Haartman, Desiré Lindberg, Neeraj Prabhakar, Tuomas Näreoja, Cecilia Sahlgren
Small
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A1 Journal article (refereed)
Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles (2016)
Desai D, Prabhakar N, Mamaeva V, Şen Karaman D, Lähdeniemi IAK, Sahlgren C, Rosenholm JM, Toivola DM
International Journal of Nanomedicine
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A1 Journal article (refereed)
Decoding breast cancer tissue-stroma interactions using species-specific sequencing (2015)
Chivukula IV, Ramskold D, Storvall H, Anderberg C, Jin SB, Mamaeva V, Sahlgren C, Pietras K, Sandberg R, Lendahl U
Breast Cancer Research
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A1 Journal article (refereed)
Genetically-encoded tools for cAMP probing and modulation in living systems (2015)
Paramonov VM, Mamaeva V, Sahlgren C, Rivero-Muller A
Frontiers in Pharmacology
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A1 Journal article (refereed)
Mesoporous silica particle-PLA–PANI hybrid scaffolds for cell-directed intracellular drug delivery and tissue vascularization (2015)
Hussein Shokry, Ulriika Vanamo, Oliver Wiltschka, Jenni Niinimäki, Martina Lerche, Kalle Levon, Mika Linden, Cecilia Sahlgren
Nanoscale
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A1 Journal article (refereed)
Novel, fast-processed crystalline and amorphous manganese oxide nanoparticles for stem cell labeling (2015)
Rosenholm JM, Korpi RM, Lammentausta E, Lehtonen S, Lehenkari P, Niemi R, Xiao W, Zhang J, Lindberg D, Gu H, Sahlgren C, Blanco Sequeiros R
Inorganic Chemistry Frontiers
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A1 Journal article (refereed)
Active targeting of mesoporous silica drug carriers enhances γ-secretase inhibitor efficacy in an in vivo model for breast cancer (2014)
Wittig R, Rosenholm JM, Haartman E, Hemming J, Genze F, Bergman L, Simmet T, Lindén M, Sahlgren C
Nanomedicine
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A1 Journal article (refereed)
Combination of magnetic field and surface functionalization for reaching synergistic effects in cellular labeling by magnetic core-shell nanospheres (2014)
Gulin-Sarfraz T, Zhang J, Desai D, Teuho J, Sarfraz J, Jiang H, Zhang C, Sahlgren C, Lindén M, Gu H, Rosenholm JM
Biomaterials Science
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A1 Journal article (refereed)
Mesoporous silica nanoparticle-based substrates for cell directed delivery of Notch signalling modulators to control myoblast differentiation (2014)
Dominique Böcking, Oliver Wiltschka, Jenni Niinimäki, Hussein Shokry, Rolf Brenner, Mika Lindén, Cecilia Sahlgren
Nanoscale
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A1 Journal article (refereed)
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner (2014)
Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, Mutvei A, Imanishi SY, Holmberg J, Jin S, Eriksson JE, Lendahl U, Sahlgren C
Cell Research
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A1 Journal article (refereed)
Core--shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application (2013)
Neeraj Prabhakar, Tuomas Näreoja, Eva von Haartman, Didem Sen Karaman, Hua Jiang, Sami Koho, Tatiana A. Dolenko, Pekka E. Hänninen, Denis I. Vlasov, Viktor G. Ralchenko,
Satoru Hosomi, Igor I. Vlasov, Cecilia Sahlgren and Jessica M. Rosenholm

Nanoscale
A1 Journal article (refereed)
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ (2013)
Jin S, Mutvei AP, Chivukula IV, Andersson ER, Ramsköld D, Sandberg R, Lee KL, Kronqvist P, Mamaeva V, Ostling P, Mpindi JP, Kallioniemi O, Screpanti I, Poellinger L, Sahlgren C, Lendahl U.
Oncogene
A1 Journal article (refereed)
Astrocytes negatively regulate neurogenesis through the Jagged1-mediated Notch pathway. (2012)
Wilhelmsson U, Faiz M, de Pablo Y, Sjöqvist M, Andersson D, Widestrand Å, Potokar M, Stenovec M, Smith PL, Shinjyo N, Pekny T, Zorec R, Ståhlberg A, Pekna M, Sahlgren C, Pekny M
STEM CELLS
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A1 Journal article (refereed)
Nanoparticles in targeted cancer therapy: mesoporous silica nanoparticles entering preclinical development stage (2012)
Jessica M. Rosenholm,Veronika Mamaeva, Cecilia Sahlgren, Mika Lindén
Nanomedicine
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A1 Journal article (refereed)
Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization (2012)
Karaman, Desai, Senthilkumar, Johansson, Råtts, Odén, Eriksson, Sahlgren, Toivola, Rosenholm
Nanoscale Research Letters
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A1 Journal article (refereed)
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms (2011)
Landor SK-J, Mutvei AP, Mamaeva V, Jin S, Busk M, Borra R, Grönroos TJ, Kronqvist P, Lendahl U, Sahlgren CM
Proceedings of the National Academy of Sciences
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A1 Journal article (refereed)
Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer (2011)
Veronika Mamaeva, Jessica M Rosenholm, Laurel Tabe Bate-Eya, Lotta Bergman, Emilia Peuhu , Alain Duchanoy, Lina E. Fortelius, Sebastian Landor, Diana M Toivola, Mika Lindén and Cecilia Sahlgren
Molecular Therapy
A1 Journal article (refereed)
Nestin as a regulator of Cdk5 in differentiating myoblasts (2011)
Pallari, Lindqvist, Torvaldson, Ferraris, He, Sahlgren, Eriksson
Molecular Biology of the Cell
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A1 Journal article (refereed)
Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors (2010)
Rosenholm, Peuhu, Bate-Eya, Eriksson, Sahlgren, Lindén
Small
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A1 Journal article (refereed)
Cancer-cell targeting and cell-specific delivery by mesoporous silica nanoparticles (2010)
Jessica Rosenholm, Cecilia Sahlgren, Mika Linden
Journal of Materials Chemistry
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A1 Journal article (refereed)
Protein kinase Czeta regulates Cdk5/p25 signaling during myogenesis (2010)
de Thonel, Ferraris, Pallari, Imanishi, Kochin, Hosokawa, Hisanaga, Sahlgren, Eriksson
Molecular Biology of the Cell
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A2 Review article, Literature review, Systematic review
Towards multifunctional, targeted drug delivery systems using mesoporous
silica nanoparticles – opportunities & challenges
(2010)
Jessica M. Rosenholm, Cecilia Sahlgren, Mika Linden
Nanoscale
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A1 Journal article (refereed)
Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems (2009)
Rosenholm, Peuhu, Eriksson, Sahlgren, Lindén
Nano Letters
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A1 Journal article (refereed)
Targeting of porous hybrid silica nanoparticles to cancer cells (2009)
Rosenholm, Meinander, Peuhu, Niemi, Eriksson, Sahlgren, Lindén
ACS Nano
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A1 Journal article (refereed)
A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death (2006)
Sahlgren, Pallari, He, Chou, Goldman, Eriksson
EMBO Journal
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A1 Journal article (refereed)
Cdk5 regulates the organization of Nestin and its association with p35. (2003)
Sahlgren CM, Mikhailov A, Vaittinen S, Pallari HM, Kalimo H, Pant HC, Eriksson JE
Molecular and Cellular Biology
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A1 Journal article (refereed)
Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase (2001)
Sahlgren, Mikhailov, Hellman, Chou, Lendahl, Goldman, Eriksson
Journal of Biological Chemistry
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A1 Journal article (refereed)
The expression of intermediate filament protein nestin as related to vimentin and desmin in regenerating skeletal muscle (2001)
Vaittinen, Lukka, Sahlgren, Hurme, Rantanen, Lendahl, Eriksson, Kalimo
Journal of Neuropathology and Experimental Neurology
A1 Journal article (refereed)
Intermediate filament protein partnership in astrocytes (1999)
Eliasson, Sahlgren, Berthold, Stakeberg, Celis, Betsholtz, Eriksson, Pekny
Journal of Biological Chemistry
A1 Journal article (refereed)
Specific and innervation-regulated expression of the intermediate filament protein nestin at neuromuscular and myotendinous junctions in skeletal muscle (1999)
Vaittinen, Lukka, Sahlgren, Rantanen, Hurme, Lendahl, Eriksson, Kalimo
American Journal of Pathology
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A1 Journal article (refereed)
Strategies to assess phosphoprotein phosphatase and protein kinase-mediated regulation of the cytoskeleton (1998)
Eriksson, Toivola, Sahlgren, Mikhailov, Härmälä-Braskén
Methods in Enzymology
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Other Research Activities


Last updated on 2018-19-09 at 19:54