PhD, Docent

Annika Meinander

Akademilektor, Cellbiologi
E-post: annika.meinander@abo.fi
Mobiltelefon: +358-469201699
Telefon: +358-2-2154602


Yrkesmässiga intressen

Regulation of inflammatory signalling by ubiquitination
Proper regulation of inflammatory responses is important to avoid development of diseases such as chronic inflammation and cancer. To be able to control unwanted inflammation, flexible but precise mechanisms are required to tune inflammatory signals in the cells. To find molecular switches that may be used to target inflammatory signalling, we aim at understanding how inflammation is regulated in cells at the molecular level. A major regulator of inflammation is the NF-κB family of transcription factors, and these factors are chronically active in many inflammatory diseases. Post-translational modifications such as ubiquitination increase the possibilities to regulate protein functions, and my laboratory studies how signalling mediated via ubiquitination regulates the NF-κB signalling pathways. As regulation of inflammation is very complicated in mammalian cells, we use the fruit fly Drosophila melanogaster as a model organism. The signalling mechanisms controlling as well ubiquitination as NF-κB responses are well conserved between mammals and flies, hence, Drosophila serves as an excellent model organism to study the basic principles of this inflammation-promoting signalling pathway.
As ubiquitination is a post-translational modification that is induced and removed in a regulated, flexible manner, it may be used as a drug target for tuning inflammatory signalling. To be able to target ubiquitination, we will investigate how ubiquitination patterns are changed during inflammation. Further, we aim to find regulators of ubiquitination as well as to determine executors of ubiquitin signalling in the NF-κB pathways. Pinpointing the changes in ubiquitination during inflammation may also allow us to develop new diagnostic markers for inflammation. As intestinal inflammation is a specific interest of ours, and as the Drosophila intestine is a recognised and convenient model for intestinal disease, we are particularly interested in targeting ubiquitination events in intestinal inflammation. As an approach to target molecules to specific cell populations of the intestinal epithelium, we will use nanoparticle-mediated delivery, an elegant and precise method that also is suitable for development of diagnostic markers for inflammation.


Forskningsområden


Referentgranskade publikationer

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Generating Germ-Free Drosophila to Study Gut-Microbe Interactions: Protocol to Rear Drosophila Under Axenic Conditions. (2018)
Christa Kietz, Vilma Pollari, Annika Meinander
Current protocols in toxicology
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila. (2018)
Anna L. Aalto, Aravind K. Mohan, Lukas Schwintzer, Sebastian Kupka, Christa Kietz, Henning Walczak, Meike Broemer, Annika Meinander
Cell Death and Differentiation
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Internal epithelia in Drosophila display rudimentary competence to form cytoplasmic networks of transgenic human vimentin (2017)
Josef Gullmets, Elin Torvaldson, Julia Lindqvist, Susumu Y. Imanishi, Pekka Taimen, Annika Meinander, and John E. Eriksson
FASEB Journal
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A2 Granskningsartikel, litteraturgranskning, systematisk granskning
Tailored approaches in drug development and diagnostics: from molecular design to biological model systems (2017)
Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A. Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi M. H. Salo-Ahen, Ronald Österbacka, John E. Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler
Advanced Healthcare Materials
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling (2012)
Meinander A, Runchel C, Tenev T, Chen L, Kim CH, Ribeiro PS, Broemer M, Leulier F, Zvelebil M, Silverman N, Meier P
EMBO Journal
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
A simple mass-action model for the eukaryotic heat shock response and its mathematical validation (2011)
Petre I, Mizera A, Hyder CL, Meinander A, Mikhailov A, Morimoto RI, Sistonen L, Eriksson JE, Back RJ
Natural Computing
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A4 Konferenspublikationer
Mathematical modeling of apoptosis as a function of c-flip turnover and at random parameter distributions (2011)
Toivonen HT, Saxen H, Westerlund M, Pettersson F, Meinander A, Eriksson JE
Springer
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Modeling reveals that dynamic regulation of c-FLIP levels determines cell-to-cell distribution of CD95-mediated apoptosis (2011)
Toivonen HT, Meinander A, Asaoka T, Westerlund M, Pettersson F, Mikhailov A, Eriksson JE, Saxén H
Journal of Biological Chemistry
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
An autocrine sphingosine-1-phosphate signaling loop enhances NF-κB-activation and survival (2010)
Blom T, Bergelin N, Meinander A, Löf C, Slotte JP, Eriksson JE, Törnquist K
BMC Cell Biology
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability (2009)
Kaunisto, Kochin, Asaoka, Mikhailov, Poukkula, Meinander, Eriksson
Cell Death and Differentiation
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Targeting of porous hybrid silica nanoparticles to cancer cells (2009)
Rosenholm, Meinander, Peuhu, Niemi, Eriksson, Sahlgren, Lindén
ACS Nano
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Opposing roles for caspase and calpain death proteases in L-glutamate-induced oxidative neurotoxicity (2008)
Elphick, Hawat, Toms, Meinander, Mikhailov, Eriksson, Kass
Toxicology and Applied Pharmacology
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Fever-like hyperthermia controls T Lymphocyte persistence by inducing degradation of cellular FLIPshort (2007)
Meinander, Söderström, Kaunisto, Poukkula, Sistonen, Eriksson
Journal of Immunology
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Live cell detection of caspase-3 activation by a Discosoma-red-fluorescent-protein-based fluorescence resonance energy transfer construct (2006)
Elphick, Meinander, Mikhailov, Richard, Toms, Eriksson, Kass
Analytical Biochemistry
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A2 Granskningsartikel, litteraturgranskning, systematisk granskning
Instant decisions: transcription-independent control of death-receptor-mediated apoptosis (2004)
Tran, Meinander, Eriksson
Trends in Biochemical Sciences
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis (2003)
Tran SEF, Meinander A, Holmström TH, Rivero-Muller A, Heiskanen KM, Linnau EK, Courtney MJ, Mosser DD, Sistonen L, Eriksson JE
Cell Death and Differentiation
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Type-2A protein phosphatase activity is required to maintain death receptor responsiveness (2003)
Härmälä-Brasken AS, Mikhailov A, Söderström TS, Meinander A, Holmström TH, Damuni Z, Eriksson JE
Oncogene
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A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)
Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1 (2001)
Holmberg, Hietakangas, Mikhailov, Rantanen, Kallio, Meinander, Hellman, Morrice, MacKintosh, Morimoto, Eriksson, Sistonen
EMBO Journal
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Senast uppdaterad 2019-02-09 vid 08:09