Slr0006-like proteins: A TsaC/TsaC2/YciO subfamily exclusive to cyanobacteria

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Carvalho Leonor L., Salminen Tiina A., Dahlström Käthe M.
Publisher: Elsevier
Publication year: 2017
Journal: Molecular Phylogenetics and Evolution
Volume number: 109
Start page: 1
End page: 10
eISSN: 1095-9513


The universally conserved TsaC/TsaC2/YciO family of proteins is essential for the N6-threonylcarbamoyladenosine modification present in almost all ANN-decoding tRNAs. Previously, the family has been grouped into the TsaC/TsaC2 and YciO subfamilies. We used sequence analysis, phylogenetic methods and homology modeling to show that a third subfamily, the Slr0006-like subfamily, exists exclusively in some cyanobacteria. The Slr0006-like proteins are solely found together with both TsaC and YciO homologs, indicating a distinct function for the Slr0006-like subfamily. Accordingly, the homology models show that the amino acids in their putative binding clefts differ significantly. Hence, we introduce a new cyanobacterial subfamily of proteins with the TsaC-domain fold, along with the generated classification rules to assign new members to the correct cyanobacterial subfamily.

Last updated on 2020-23-09 at 05:41