Porous SiO2 nanofiber grafted novel bioactive glass–ceramic coating: A structural scaffold for uniform apatite precipitation and oriented cell proliferation on inert implant

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Indranee Das, Goutam De, Leena Hupa, Pekka K. Vallittu
Publication year: 2016
Journal: Materials Science and Engineering: C
Volume number: 62
Start page: 206
End page: 214
eISSN: 1873-0191


A composite bioactive glass-ceramic coating grafted with porous silica nanofibers was fabricated on inert glass to provide a structural scaffold favoring uniform apatite precipitation and oriented cell proliferation. The coating surfaces were investigated thoroughly before and after immersion in simulated body fluid. In addition, the proliferation behavior of fibroblast cells on the surface was observed for several culture times. The nanofibrous exterior of this composite bioactive coating facilitated homogeneous growth of flake-like carbonated hydroxyapatite layer within a short period of immersion. Moreover, the embedded porous silica nanofibers enhanced hydrophilicity which is required for proper cell adhesion on the surface. The cells proliferated well following a particular orientation on the entire coating by the assistance of nanofibrous scaffold-like structural matrix. This newly engineered composite coating was effective in creating a biological structural matrix favorable for homogeneous precipitation of calcium phosphate, and organized cell growth on the inert glass surface.


bioactive coatings, bioactive glass, Bioactive glass-ceramic, Carbonated hydroxyapatite, Cell Proliferation, Coating, Nanofiber, Scaffold

Last updated on 2019-13-11 at 03:25