Isomerization of bicyclic terpene epoxides into allylic alcohols without changing of the initial structure

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Yu.S. Demidova, O.V. Ardashov, O.A. Simakova, I.L. Simakova, K.P. Volcho, N.F. Salakhutdinov, D.Yu. Murzin
Publication year: 2014
Journal: Journal of Molecular Catalysis A: Chemical
Volume number: 388-389
Start page: 162
End page: 166
eISSN: 1873-3891


Abstract

A novel method of (1S,2R,3R,5R)-6,6-dimethy1-4-methylenebicyclo[3.1.1]heptane-2,3-diol synthesis, which is a valuable intermediate in the synthesis of a perspective potent anti-Parkinson drugs, in the presence of TiO2 was proposed. Catalytic activity of TiO2 in the bicyclic terpene epoxides isomerization to corresponding allylic alcohols without changing of the initial structure was demonstrated, contrary to titania-supported Au catalysts which promoted rearrangement with predominant formation of a cyclopentene alpha-hydroxy ketone.

Last updated on 2020-28-05 at 01:32