Gas-foamed poly(lactide-co-glycolide) and poly(lactide-co-glycolide) with bioactive glass fibers demonstrate insufficient bone repair in lapine osteochondral defects

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Eve Salonius, Virpi Muhonen, Kalle Lehto, Elina Järvinen, Tuomo Pyhältö, Markus Hannula, Antti S. Aula, Peter Uppstu, Anne-Marie Haaparanta, Ari Rosling, Minna Kellomäki, Ilkka Kiviranta
Publication year: 2019
Journal: Journal of Tissue Engineering and Regenerative Medicine
Journal acronym: J Tissue Eng Regen Med


Deep osteochondral defects may leave voids in the subchondral bone,
increasing the risk of joint structure collapse. To ensure a stable
foundation for the cartilage repair, bone grafts can be used for filling
these defects. Poly(lactide‐co‐glycolide) (PLGA) is a biodegradable
material that improves bone healing and supports bone matrix deposition.
We compared the reparative capacity of two investigative macroporous
PLGA‐based biomaterials with two commercially available bone graft
substitutes in the bony part of an intra‐articular bone defect created
in the lapine femur. New Zealand white rabbits (n = 40) were
randomized into five groups. The defects, 4 mm in diameter and 8 mm
deep, were filled with neat PLGA; a composite material combining PLGA
and bioactive glass fibres (PLGA–BGf); commercial beta‐tricalcium
phosphate (β‐TCP) granules; or commercial bioactive glass (BG) granules.
The fifth group was left untreated for spontaneous repair. After three
months, the repair tissue was evaluated with X‐ray microtomography and
histology. Relative values comparing the operated knee with its
contralateral control were calculated. The relative bone volume fraction
(∆BV/TV) was largest in the β‐TCP group (p ≤ 0.012),
which also showed the most abundant osteoid. BG resulted in improved
bone formation, whereas defects in the PLGA–BGf group were filled with
fibrous tissue. Repair with PLGA did not differ from spontaneous repair.
The PLGA, PLGA–BGf, and spontaneous groups showed thicker and sparser
trabeculae than the commercial controls. We conclude that bone repair
with β‐TCP and BG granules was satisfactory, whereas the investigational
PLGA‐based materials were only as good as or worse than spontaneous

Last updated on 2019-26-05 at 04:27