Development of Oromucosal Dosage Forms by Combining Electrospinning and Inkjet Printing

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Palo Mirja, Kogermann Karin, Laidmäe Ivo, Meos Andres, Preis Maren, Heinämäki Jyrki, Sandler Niklas
Förläggare: American Chemical Society
Publiceringsår: 2017
Tidskrift: Molecular Pharmaceutics
Tidskriftsakronym: Mol. Pharmaceutics
Volym: 14
Nummer: 3
Artikelns första sida, sidnummer: 808
Artikelns sista sida, sidnummer: 820


Abstrakt

Abstract Image

Printing technology has been shown to enable flexible fabrication of solid dosage forms for personalized drug therapy. Several methods can be applied for tailoring the properties of the printed pharmaceuticals. In this study, the use of electrospun fibrous substrates in the fabrication of inkjet-printed dosage forms was investigated. A single-drug formulation with lidocaine hydrochloride (LH) and a combination drug system containing LH and piroxicam (PRX) for oromucosal administration were prepared. The LH was deposited on the electrospun and cross-linked gelatin substrates by inkjet printing, whereas PRX was incorporated within the substrate fibers during electrospinning. The solid state analysis of the electrospun substrates showed that PRX was in an amorphous state within the fibers. Furthermore, the results indicated the entrapment and solidification of the dissolved LH within the fibrous gelatin matrix. The printed drug amount (2–3 mg) was in good correlation with the theoretical dose calculated based on the printing parameters. However, a noticeable degradation of the printed LH was detected after a few months. An immediate release (over 85% drug release after 8 min) of both drugs from the printed dosage forms was observed. In conclusion, the prepared electrospun gelatin scaffolds were shown to be suitable substrates for inkjet printing of oromucosal formulations. The combination of electrospinning and inkjet printing allowed the preparation of a dual drug system.


Nyckelord

cross-linked gelatin, electrospinning, inkjet printing, lidocaine hydrochloride, oromucosal drug delivery, piroxicam

Senast uppdaterad 2019-24-10 vid 03:54