3D printed drug delivery devices: perspectives and technical challenges

A2 Granskningsartikel, litteraturgranskning, systematisk granskning


Interna författare/redaktörer


Publikationens författare: Palo M, Holländer J, Suominen J, Yliruusi J, Sandler N
Förläggare: Taylor & Francis
Publiceringsår: 2017
Tidskrift: Expert Review of Medical Devices
Volym: 14
Nummer: 9
Artikelns första sida, sidnummer: 685
Artikelns sista sida, sidnummer: 696
ISSN: 1743-4440


Abstrakt

Introduction: The technological advancements in the pharmaceutical field are constantly improving and provide various possibilities for meeting the needs of personalized drug therapy. The three-dimensional (3D) printing technology has endless potential in the fabrication of patient-specific drug delivery devices (DDD) and dosage forms as the technological development is progressing. Moreover, the rapidly evolving research on 3D printed DDD has enabled us to determine several challenges related to the manufacturing and marketing of personalized drug delivery systems.

Areas covered: In this review, an overview is provided on the relevant accomplishments in the development of 3D printed drug delivery systems, as well as the technical challenges surrounding the 3D printing of personalized drug-loaded medical devices and dosage forms. Furthermore, observations are presented on the future perspectives of pharmaceutical 3D printing.

Expert commentary: The 3D printing has enabled the fabrication of prototypes of DDD with varying complexity and shows that customization of drug products is possible. There is potential to improve patient-specific drug therapies of the future using printing technologies. The technological advancements, new scientific concepts, interdisciplinary work and defined regulatory guidelines will continue to support and strengthen the prospects of 3D printing as an option in the manufacture of medical products.


Nyckelord

Fused deposition modelling, oral drug delivery, Personalized medicine, Solid freeform fabrication, Tailored dosage forms, Three-dimensional printing

Senast uppdaterad 2019-12-11 vid 03:29