Modeling of a hybrid Langmuir adsorption isotherm for describing interactions between drug molecules and silica surfaces

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Thomas Sandberg, Christian Weinberger, Didem Şen Karaman, Jessica M. Rosenholm
Publisher: American Pharmaceutical Association
Publication year: 2018
Journal: Journal of Pharmaceutical Sciences
Volume number: 107
Issue number: 5
Start page: 1392
End page: 1397
ISSN: 0022-3549
eISSN: 1520-6017


The interaction between disulfiram (Antabus®) and silica was studied experimentally by adsorption from apolar solvent onto highly porous silica material (Santa Barbara Amorphous material-3, SBA-3) with large surface area. The adsorption isotherm was fitted to the Langmuir model by accounting two different affinities contributing to the overall behavior, which were attributed to two different types of silanol groups (i.e. geminal and vicinal) present on amorphous silica surfaces. This assumption was supported by theoretical calculations. Additionally, the model could describe the adsorption of ibuprofen to the carrier material, indicating that the model bears big potential for describing the interactions between silica surfaces and drug molecules.


Ab initio calculations, Adsorption, Silica

Last updated on 2020-28-01 at 05:06