Serotonergic polymorphisms in the control of ejaculation

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: Patrick Jern, Daniel Ventus
Publication year: 2017
Journal: Molecular and Cellular Endocrinology
eISSN: 1872-8057


Serotonin has long been
implicated in the regulation of the processes that trigger the
ejaculatory reflex. Most evidence of serotonergic involvement is,
however, indirect, stemming either from studies on rodents or clinical
trials investigating effects of serotonergic drugs. In the past decade,
emerging evidence for heritability (i.e., genetic effects) of premature
ejaculation (PE) symptoms has spawned a number of scholarly attempts to
identify genes that regulate ejaculation, most of which have focused on
candidate genes related to the serotonergic system. The aim of the
present review article was to summarize the literature concerning
genetic association studies of PE, with focus on serotonergic genes.
However, methodological obstacles relating to the candidate gene
approach predict that a priori hypotheses regarding candidate genes are
likely to generate ambiguous and spurious results if samples (e.g., if
samples are underpowered and/or stratified). Attempts to replicate
reported novel associations between PE symptoms and serotonergic
candidate genes have largely failed (thereby adding to the growing body
of evidence casting doubt on the reliability of the candidate gene
approach), and at present, it is not possible to determine with
acceptable certainty which serotonergic genes, if any, are involved in
ejaculatory function.

Last updated on 2019-21-05 at 05:22