The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Marthe-Susanna Wegner, Lisa Gruber, Peter Mattjus, Gerd Geisslinger, Sabine Grösch
Publisher: BioMed Central (BMC)
Publication year: 2018
Journal: BMC Cancer
Volume number: 18
Issue number: 1


Abstract




















The UDP-glucose
ceramide glycosyltransferase (UGCG) is a key enzyme in the sphingolipid
metabolism by generating the precursor for all glycosphingolipids (GSL), essential
for proper cell function. But the UGCG is also overexpressed in several cancer
types and correlates with multidrug
resistance protein 1
(MDR1) gene
expression. This enzyme is responsible for efflux of toxic substances and
protects cancer cells from cell damage through chemotherapeutic agents. Studies
showed a connection between UGCG and MDR1
overexpression and multidrug resistance development, but the precise mechanisms
underlying are unknown. Here, we give an overview about the UGCG and its
connection to MDR1 in multidrug
resistant cells. Furthermore, we focus on UGCG transcriptional regulation, the
impact of UGCG on cellular signaling pathways and the effect of UGCG and MDR1 on the lipid composition of
membranes and how this could impact multidrug resistance development. To our
knowledge, this is the first review presenting an overview about UGCG with
focus on the relationship to MDR1 in
the process of multidrug resistance development.


Last updated on 2019-23-09 at 04:42