Conducting Polymeric Nanocomposites with a Three-Dimensional Co-flow Microfluidics Platform

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

Interna författare/redaktörer

Publikationens författare: Ma X, Zhang Y, Weisensee K
Förläggare: MDPI
Publiceringsår: 2019
Tidskrift: Micromachines
Tidskriftsakronym: MICROMACHINES-BASEL
Volym: 10
Nummer: 6
Antal sidor: 1
eISSN: 2072-666X


The nanoprecipitation of polymers is of great interest in biological and
medicinal applications. Many approaches are available, but few
generalized methods can fabricate structurally different biocompatible
polymers into nanosized particles with a narrow distribution in a
high-throughput manner. We simply integrate a glass slide, capillary,
and metal needle into a simple microfluidics device. Herein, a detailed
protocol is provided for using the glass capillary and slides to
fabricate the microfluidics devices used in this work. To demonstrate
the generality of our nanoprecipitation approach and platform, four
(semi)natural polymers—acetalated dextran (Ac-DEX), spermine acetalated
dextran (Sp-Ac-DEX), poly(lactic-co-glycolic acid) (PLGA), and
chitosan—were tested and benchmarked by the polymeric particle size and
polydispersity. More importantly, the principal objective was to explore
the influence of some key parameters on nanoparticle size due to its
importance for a variety of applications. The polymer concentration, the
solvent/non-solvent volume rate/ratio, and opening of the inner
capillary were varied so as to obtain polymeric nanoparticles (NPs).
Dynamic light scattering (DLS), transmission electron microscopy (TEM),
and optical microscopy are the main techniques used to evaluate the
nanoprecipitation output. It turns out that the concentration of polymer
most strongly determines the particle size and distribution, followed
by the solvent/non-solvent volume rate/ratio, whereas the opening of the
inner capillary shows a minor effect. The obtained NPs were smooth
spheres with adjustable particle diameters and polymer-dependent surface
potentials, both negative and positive.

Senast uppdaterad 2020-06-04 vid 06:35