9-Norlignans: Occurrence, Properties and Their Semisynthetic Preparation from Hydroxymatairesinol

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Patrik Eklund P, Jan-Erik Raitanen
Publisher: MDPI
Publication year: 2019
Journal: Molecules
Journal acronym: MOLECULES
Volume number: 24
Issue number: 2
Number of pages: 12
ISSN: 1420-3049
eISSN: 1420-3049


Lignans, neolignans, norlignans and norneolignans constitute a large class of phenolic natural compounds. 9-Norlignans, here defined to contain a -' bond between the two phenylpropanoid units and to lack carbon number 9 from the parent lignan structure, are the most rarely occurring compounds within this class of natural compounds. We present here an overview of the structure, occurrence and biological activity of thirty-five 9-norlignans reported in the literature to date. In addition, we report the semisynthetic preparation of sixteen 9-norlignans using the natural lignan hydroxymatairesinol obtained from spruce knots, as starting material. 9-Norlignans are shown to exist in different species and to have various biological activities, and they may therefore serve as lead compounds for example for the development of anticancer agents. Hydroxymatairesinol is shown to be a readily available starting material for the preparation of norlignans of the imperanene, vitrofolal and noralashinol family.


9-norlignans, bioactivity, norlignans, semisynthesis

Last updated on 2020-26-05 at 06:11