Peptides in lipid bilayers: the power of simple models

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: J Antoinette Killian, Thomas KM Nyholm
Publisher: Elsevier
Publication year: 2006
Journal: Current Opinion in Structural Biology
Journal acronym: Curr Opin Struct Biol
Volume number: 16
Issue number: 4
Start page: 473
End page: 479
ISSN: 0959-440X


Interactions between proteins and lipids lie at the heart of virtually all membrane processes, but on a molecular level they are still poorly understood. Nowadays, simple model systems comprising designed transmembrane peptides in synthetic lipid bilayers are increasingly being recognized as powerful tools to uncover basic principles of protein-lipid interactions. Such model systems enable detailed analysis of how the properties of lipids influence the structure and dynamics of transmembrane helices, how these helices are anchored at the lipid-water interface, and how the length and composition of transmembrane segments influence the organization and dynamics of membrane lipids. In addition, well-characterized model systems have proven useful to refine computational approaches and to develop new techniques for studies of protein-lipid interactions.

Last updated on 2020-08-07 at 04:33

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