Biomimetic inks based on hemicellulose and nanocellulose for 3D printing

A4 Conference proceedings

Internal Authors/Editors

Publication Details

List of Authors: Wenyang Xu, Xue Zhang, Peirui Yang, Otto Långvik, Xiaoju Wang, Yongchao Zhang, Fang Cheng, Monika Österberg, Stefan M. Willför, Chunlin Xu
Place: Chiba, Japan
Publication year: 2019
Publisher: TAPPI Press
Book title: International Conference on Nanotechnology for Renewable Materials 2019
Start page: 938
ISBN: 978-1-5108-8834-0


Three-dimensional (3D) printing
supplies a facile bottom-up approach allowing the patterning of biocompatible
hydrogels into 3D tissue-mimicking scaffolds towards biomedical application.
Cellulose nanofibrils (CNFs) in the form of hydrogel with the outstanding
properties such as biocompatibility, in vitro biodegradability, flexibility,
and excellent mechanical properties show a promising potential in mimicking the
native extracellular matrices (ECM). Thus, CNFs as an emerging platform
material in the ink formulation for 3D printing have attracted increasing
interest worldwide. In our study, we developed a surface-engineered biomimetic
ink formulation with CNFs and cross-linkable hemicellulose derivatives for
UV-aided extrusion printing, being inspired by the intrinsic affinity of
hemicellulose to cellulose. A facile aqueous-based approach was firstly
established for the synthesis of a series of UV cross-linkable
galactoglucomanan methacrylates (GGMMAs) with tunable substitution degrees. The
chemical structures of GGMMAs were thoroughly characterized by NMR and size
exclusion chromatography. The influence of methacrylation on the adsorption of
GGM to cellulose was studied with a quartz crystal microbalance to assess the
adsorption level. The formulated inks showed a rapid gelation time window
verified by photo-rheology, which facilities the utilization of these
wood-based biopolymers as the feeding ink for the extrusion-based 3D printing.
More significantly, a wide and tunable spectrum of different hydrogels with
different mechanical properties could be achieved by varying the substitution
degree in GGMMA and the compositional ratio between GGMMA and CNF. These
materials show an excellent potential as a versatile culturing platform for
different cell lines.


3D printing, Nanocellulose

Last updated on 2020-23-09 at 06:14