Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Be̅rziņš K, Fraser-Miller SJ, Rades T, Gordon KC
Publisher: American Chemical Society
Publication year: 2019
Journal: Molecular Pharmaceutics
Volume number: 16
Issue number: 8
Start page: 3678
End page: 3686
ISSN: 1543-8384


A series of melt-quenched disks of amorphous celecoxib were obtained using two different cooling rates (>100 °C/min and ∼25–30 °C/min) and subjected to different compression pressures (125, 250, and 500 MPa) and dwell times (0, 30, and 60 s). The kinetics of crystallization for these differently prepared melt-quenched disks were probed using a number of methods. Low-frequency Raman spectroscopy was used to monitor isothermal crystallization kinetics, whereas dynamic differential scanning calorimetry served as a complimentary technique to identify changes in form. Although both compression parameters destabilized the amorphous celecoxib, the dwell time was found to have a more critical overall effect. Additionally, the sample history was affirmed to be a factor for limiting the magnitude of compression-induced destabilization.

Last updated on 2020-29-03 at 05:56