In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Francisco R. López-Picón, Anna K. Kirjavainen, Sarita Forsback, Jatta S. Takkinen, Dan Peters, Merja Haaparanta-Solin, Olof Solin
Publisher: Ivyspring International Publisher
Publication year: 2019
Journal: Theranostics
Volume number: 9
Issue number: 1
Start page: 11
End page: 19


Abstract

Norepinephrine modulates cognitive processes such as working and
episodic memory. Pathological changes in norepinephrine and
norepinephrine transporter (NET) function and degeneration of the locus
coeruleus produce irreversible impairments within the whole
norepinephrine system, disrupting cognitive processes. Monitoring these
changes could enhance diagnostic accuracy and support development of
novel therapeutic components for several neurodegenerative diseases.
Thus, we aimed to develop a straightforward nucleophilic fluorination
method with high molar activity for the novel NET radiotracer [18F]NS12137 and to demonstrate the ability of [18F]NS12137 to quantify changes in NET expression.


Last updated on 2020-28-05 at 02:17