Rapid spread of mannan to the immune system, skin and joints within 6 hours after local exposure

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: C Hagert, R Siitonen, X-G Li, H Liljenbäck, A Roivainen, R Holmdahl
Förläggare: Wiley
Publiceringsår: 2019
Tidskrift: Clinical and Experimental Immunology
Volym: 196
Nummer: 3
Artikelns första sida, sidnummer: 383
Artikelns sista sida, sidnummer: 391


Abstrakt

Psoriasis (Ps), psoriatic arthritis (PsA) and rheumatoid arthritis (RA)
are common diseases dependent on environmental factors that activate the
immune system in unknown ways. Mannan is a group of polysaccharides
common in the environment; they are potentially pathogenic, because at
least some of them induce Ps‐, PsA‐ and RA‐like inflammation in mice.
Here, we used positron emission tomography/computed tomography to
examine in‐vivo transport and spread of mannan labelled with fluorine‐18 [18F].
The results showed that mannan was transported to joints (knee) and
bone marrow (tibia) of mice within 6 h after intraperitoneal injection.
The time it took to transport mannan, and its presence in blood,
indicated cellular transport of mannan within the circulatory system. In
addition, mannan was filtered mainly through the spleen and liver. [18F]fluoromannan
was excreted via kidneys, small intestine and, to some extent, the
mouth. In conclusion, mannan reaches joints rapidly after injection,
which may explain why mannan‐induced inflammatory disease is targeted to
these tissues.


Senast uppdaterad 2020-27-05 vid 02:36