Filopodia in cell adhesion, 3D migration and cancer cell invasion

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: Guillauame Jacquemet, Hellyeh Hamidi, Johanna Ivaska
Publication year: 2015
Journal: Current Opinion in Cell Biology
Journal acronym: Curr Opin Cell Biol
Volume number: 36
Start page: 23
End page: 31
ISSN: 1879-0410


This review discusses recent advances in our understanding of the role filopodia and filopodia-like structures in cell adhesion and three dimensional (3D) cell migration both in vitro and in vivo. In particular, we focus on recent advances demonstrating that filopodia are involved in substrate tethering and environment sensing in vivo. We further discuss the emerging role of filopodia and filopodial proteins in tumor dissemination as mounting in vitro, in vivo and clinical evidence suggest that filopodia drive cancer cell invasion and highlight filopodia proteins as attractive therapeutic targets. Finally, we outline outstanding questions that remain to be addressed to elucidate the role of filopodia during 3D cell migration.

Last updated on 2020-10-07 at 07:00