Cell matrix adhesion in cell migration

A2 Review article, Literature review, Systematic review


Internal Authors/Editors


Publication Details

List of Authors: Conway James R.W., Jacquemet Guillaume
Publication year: 2019
Journal: Essays in Biochemistry
Journal acronym: Essays Biochem
ISSN: 1744-1358


Abstract

The ability of cells to migrate is a fundamental physiological process involved in embryonic development, tissue homeostasis, immune surveillance and wound healing. In order for cells to migrate, they must interact with their environment using adhesion receptors, such as integrins, and form specialized adhesion complexes that mediate responses to different extracellular cues. In this review, we discuss the role of integrin adhesion complexes (IACs) in cell migration, highlighting the layers of regulation that are involved, including intracellular signalling cascades, mechanosensing and reciprocal feedback to the extracellular environment. We also discuss the role of IACs in extracellular matrix remodeling and how they impact upon cell migration.

Last updated on 2019-13-11 at 04:47